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N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine -1(2H)-carbox-amide (BCTC), a novel, orally effective vanilloid receptor 1 antagonist with analgesic properties: I. in vitro characterization and pharmacokinetic properties.
Valenzano KJ, Grant ER, Wu G, Hachicha M, Schmid L, Tafesse L, Sun Q, Rotshteyn Y, Francis J, Limberis J, Malik S, Whittemore ER, Hodges D. Valenzano KJ, et al. Among authors: hachicha m. J Pharmacol Exp Ther. 2003 Jul;306(1):377-86. doi: 10.1124/jpet.102.045674. Epub 2003 Apr 29. J Pharmacol Exp Ther. 2003. PMID: 12721338
4-(2-pyridyl)piperazine-1-carboxamides: potent vanilloid receptor 1 antagonists.
Sun Q, Tafesse L, Islam K, Zhou X, Victory SF, Zhang C, Hachicha M, Schmid LA, Patel A, Rotshteyn Y, Valenzano KJ, Kyle DJ. Sun Q, et al. Among authors: hachicha m. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3611-6. doi: 10.1016/s0960-894x(03)00759-5. Bioorg Med Chem Lett. 2003. PMID: 14505681
Synergistic effect of interleukin-1 beta and tumor necrosis factor alpha on interleukin-8 gene expression in synovial fibroblasts. Evidence that interleukin-8 is the major neutrophil-activating chemokine released in response to monokine activation.
Rathanaswami P, Hachicha M, Wong WL, Schall TJ, McColl SR. Rathanaswami P, et al. Among authors: hachicha m. Arthritis Rheum. 1993 Sep;36(9):1295-304. doi: 10.1002/art.1780360914. Arthritis Rheum. 1993. PMID: 8216423
208 results