Wienkers LC - Search Results

1

Inhibition of cytochrome P450 2D6: structure-activity studies using a series of quinidine and quinine analogues.

Hutzler JM, Walker GS, Wienkers LC. Hutzler JM, et al. Among authors: wienkers lc. Chem Res Toxicol. 2003 Apr;16(4):450-9. doi: 10.1021/tx025674x. Chem Res Toxicol. 2003. PMID: 12703961

2

Inhibition of cytochrome P450 3A4 by a pyrimidineimidazole: Evidence for complex heme interactions.

Hutzler JM, Melton RJ, Rumsey JM, Schnute ME, Locuson CW, Wienkers LC. Hutzler JM, et al. Among authors: wienkers lc. Chem Res Toxicol. 2006 Dec;19(12):1650-9. doi: 10.1021/tx060198m. Chem Res Toxicol. 2006. PMID: 17173379

3

Effect of carbonate anion on cytochrome P450 2D6-mediated metabolism in vitro: the potential role of multiple oxygenating species.

Hutzler JM, Powers FJ, Wynalda MA, Wienkers LC. Hutzler JM, et al. Among authors: wienkers lc. Arch Biochem Biophys. 2003 Sep 15;417(2):165-75. doi: 10.1016/s0003-9861(03)00350-3. Arch Biochem Biophys. 2003. PMID: 12941298

4

Mechanism-based inactivation of cytochrome P450 2D6 by 1-[(2-ethyl-4-methyl-1H-imidazol-5-yl)methyl]- 4-[4-(trifluoromethyl)-2-pyridinyl]piperazine: kinetic characterization and evidence for apoprotein adduction.

Hutzler JM, Steenwyk RC, Smith EB, Walker GS, Wienkers LC. Hutzler JM, et al. Among authors: wienkers lc. Chem Res Toxicol. 2004 Feb;17(2):174-84. doi: 10.1021/tx034199f. Chem Res Toxicol. 2004. PMID: 14967005

5

Assessment of the metabolism and intrinsic reactivity of a novel catechol metabolite.

Hutzler JM, Melton RJ, Rumsey JM, Thompson DC, Rock DA, Wienkers LC. Hutzler JM, et al. Among authors: wienkers lc. Chem Res Toxicol. 2008 May;21(5):1125-33. doi: 10.1021/tx700429v. Epub 2008 Apr 12. Chem Res Toxicol. 2008. PMID: 18407675

6

In vitro metabolism of clindamycin in human liver and intestinal microsomes.

Wynalda MA, Hutzler JM, Koets MD, Podoll T, Wienkers LC. Wynalda MA, et al. Among authors: wienkers lc. Drug Metab Dispos. 2003 Jul;31(7):878-87. doi: 10.1124/dmd.31.7.878. Drug Metab Dispos. 2003. PMID: 12814964

7

Activation of cytochrome P450 2C9-mediated metabolism: mechanistic evidence in support of kinetic observations.

Hutzler JM, Wienkers LC, Wahlstrom JL, Carlson TJ, Tracy TS. Hutzler JM, et al. Among authors: wienkers lc. Arch Biochem Biophys. 2003 Feb 1;410(1):16-24. doi: 10.1016/s0003-9861(02)00665-3. Arch Biochem Biophys. 2003. PMID: 12559973

8

Catalytic turnover of pyrene by CYP3A4: evidence that cytochrome b5 directly induces positive cooperativity.

Jushchyshyn MI, Hutzler JM, Schrag ML, Wienkers LC. Jushchyshyn MI, et al. Among authors: wienkers lc. Arch Biochem Biophys. 2005 Jun 1;438(1):21-8. doi: 10.1016/j.abb.2005.02.027. Epub 2005 Mar 5. Arch Biochem Biophys. 2005. PMID: 15910734

9

Mechanism-based inactivation of cytochrome P450 2B1 by 7-ethynylcoumarin: verification of apo-P450 adduction by electrospray ion trap mass spectrometry.

Regal KA, Schrag ML, Kent UM, Wienkers LC, Hollenberg PF. Regal KA, et al. Among authors: wienkers lc. Chem Res Toxicol. 2000 Apr;13(4):262-70. doi: 10.1021/tx990195s. Chem Res Toxicol. 2000. PMID: 10775326

10

Time-dependent inactivation of P450 3A4 by raloxifene: identification of Cys239 as the site of apoprotein alkylation.

Baer BR, Wienkers LC, Rock DA. Baer BR, et al. Among authors: wienkers lc. Chem Res Toxicol. 2007 Jun;20(6):954-64. doi: 10.1021/tx700037e. Epub 2007 May 12. Chem Res Toxicol. 2007. PMID: 17497897

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