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Page 1
Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue.
Laffitte BA, Chao LC, Li J, Walczak R, Hummasti S, Joseph SB, Castrillo A, Wilpitz DC, Mangelsdorf DJ, Collins JL, Saez E, Tontonoz P. Laffitte BA, et al. Among authors: collins jl. Proc Natl Acad Sci U S A. 2003 Apr 29;100(9):5419-24. doi: 10.1073/pnas.0830671100. Epub 2003 Apr 15. Proc Natl Acad Sci U S A. 2003. PMID: 12697904 Free PMC article.
Synthetic LXR ligand inhibits the development of atherosclerosis in mice.
Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. Joseph SB, et al. Among authors: collins jl, collins ar. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9. doi: 10.1073/pnas.112059299. Proc Natl Acad Sci U S A. 2002. PMID: 12032330 Free PMC article.
Autoregulation of the human liver X receptor alpha promoter.
Laffitte BA, Joseph SB, Walczak R, Pei L, Wilpitz DC, Collins JL, Tontonoz P. Laffitte BA, et al. Among authors: collins jl. Mol Cell Biol. 2001 Nov;21(22):7558-68. doi: 10.1128/MCB.21.22.7558-7568.2001. Mol Cell Biol. 2001. PMID: 11604492 Free PMC article.
Liver X receptor activators display anti-inflammatory activity in irritant and allergic contact dermatitis models: liver-X-receptor-specific inhibition of inflammation and primary cytokine production.
Fowler AJ, Sheu MY, Schmuth M, Kao J, Fluhr JW, Rhein L, Collins JL, Willson TM, Mangelsdorf DJ, Elias PM, Feingold KR. Fowler AJ, et al. Among authors: collins jl. J Invest Dermatol. 2003 Feb;120(2):246-55. doi: 10.1046/j.1523-1747.2003.12033.x. J Invest Dermatol. 2003. PMID: 12542530 Free article.
Discovery of substituted maleimides as liver X receptor agonists and determination of a ligand-bound crystal structure.
Jaye MC, Krawiec JA, Campobasso N, Smallwood A, Qiu C, Lu Q, Kerrigan JJ, De Los Frailes Alvaro M, Laffitte B, Liu WS, Marino JP Jr, Meyer CR, Nichols JA, Parks DJ, Perez P, Sarov-Blat L, Seepersaud SD, Steplewski KM, Thompson SK, Wang P, Watson MA, Webb CL, Haigh D, Caravella JA, Macphee CH, Willson TM, Collins JL. Jaye MC, et al. Among authors: collins jl. J Med Chem. 2005 Aug 25;48(17):5419-22. doi: 10.1021/jm050532w. J Med Chem. 2005. PMID: 16107141
Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.
Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL. Chao EY, et al. Among authors: collins jl. J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u. J Med Chem. 2008. PMID: 18800767
ApoE promotes the proteolytic degradation of Abeta.
Jiang Q, Lee CY, Mandrekar S, Wilkinson B, Cramer P, Zelcer N, Mann K, Lamb B, Willson TM, Collins JL, Richardson JC, Smith JD, Comery TA, Riddell D, Holtzman DM, Tontonoz P, Landreth GE. Jiang Q, et al. Among authors: collins jl. Neuron. 2008 Jun 12;58(5):681-93. doi: 10.1016/j.neuron.2008.04.010. Neuron. 2008. PMID: 18549781 Free PMC article.
282 results