Smith KA - Search Results

1

Therapeutic use of IL-2 to enhance antiviral T-cell responses in vivo.

Blattman JN, Grayson JM, Wherry EJ, Kaech SM, Smith KA, Ahmed R. Blattman JN, et al. Among authors: smith ka. Nat Med. 2003 May;9(5):540-7. doi: 10.1038/nm866. Epub 2003 Apr 14. Nat Med. 2003. PMID: 12692546

2

PD-1 combination therapy with IL-2 modifies CD8⁺ T cell exhaustion program.

Hashimoto M, Araki K, Cardenas MA, Li P, Jadhav RR, Kissick HT, Hudson WH, McGuire DJ, Obeng RC, Wieland A, Lee J, McManus DT, Ross JL, Im SJ, Lee J, Lin JX, Hu B, West EE, Scharer CD, Freeman GJ, Sharpe AH, Ramalingam SS, Pellerin A, Teichgräber V, Greenleaf WJ, Klein C, Goronzy JJ, Umaña P, Leonard WJ, Smith KA, Ahmed R. Hashimoto M, et al. Among authors: smith ka. Nature. 2022 Oct;610(7930):173-181. doi: 10.1038/s41586-022-05257-0. Epub 2022 Sep 28. Nature. 2022. PMID: 36171288 Free PMC article.

3

Manipulating both the inhibitory and stimulatory immune system towards the success of therapeutic vaccination against chronic viral infections.

Ha SJ, West EE, Araki K, Smith KA, Ahmed R. Ha SJ, et al. Among authors: smith ka. Immunol Rev. 2008 Jun;223:317-33. doi: 10.1111/j.1600-065X.2008.00638.x. Immunol Rev. 2008. PMID: 18613845 Review.

4

Prolonged interleukin-2Ralpha expression on virus-specific CD8+ T cells favors terminal-effector differentiation in vivo.

Kalia V, Sarkar S, Subramaniam S, Haining WN, Smith KA, Ahmed R. Kalia V, et al. Among authors: smith ka. Immunity. 2010 Jan 29;32(1):91-103. doi: 10.1016/j.immuni.2009.11.010. Epub 2010 Jan 21. Immunity. 2010. PMID: 20096608 Free article.

5

PD-L1 blockade synergizes with IL-2 therapy in reinvigorating exhausted T cells.

West EE, Jin HT, Rasheed AU, Penaloza-Macmaster P, Ha SJ, Tan WG, Youngblood B, Freeman GJ, Smith KA, Ahmed R. West EE, et al. Among authors: smith ka. J Clin Invest. 2013 Jun;123(6):2604-15. doi: 10.1172/JCI67008. Epub 2013 May 15. J Clin Invest. 2013. PMID: 23676462 Free PMC article.

6

Autocrine and paracrine IL-2 signals collaborate to regulate distinct phases of CD8 T cell memory.

Toumi R, Yuzefpolskiy Y, Vegaraju A, Xiao H, Smith KA, Sarkar S, Kalia V. Toumi R, et al. Among authors: smith ka. Cell Rep. 2022 Apr 12;39(2):110632. doi: 10.1016/j.celrep.2022.110632. Cell Rep. 2022. PMID: 35417685 Free article.

7

Contrasting effects of low-dose IL-2 on vaccine-boosted simian immunodeficiency virus (SIV)-specific CD4+ and CD8+ T cells in macaques chronically infected with SIVmac251.

Nacsa J, Edghill-Smith Y, Tsai WP, Venzon D, Tryniszewska E, Hryniewicz A, Moniuszko M, Kinter A, Smith KA, Franchini G. Nacsa J, et al. Among authors: smith ka. J Immunol. 2005 Feb 15;174(4):1913-21. doi: 10.4049/jimmunol.174.4.1913. J Immunol. 2005. PMID: 15699118

8

Vaccination of macaques with long-standing SIVmac251 infection lowers the viral set point after cessation of antiretroviral therapy.

Tryniszewska E, Nacsa J, Lewis MG, Silvera P, Montefiori D, Venzon D, Hel Z, Parks RW, Moniuszko M, Tartaglia J, Smith KA, Franchini G. Tryniszewska E, et al. Among authors: smith ka. J Immunol. 2002 Nov 1;169(9):5347-57. doi: 10.4049/jimmunol.169.9.5347. J Immunol. 2002. PMID: 12391256

9

Identification of Cellular Sources of IL-2 Needed for Regulatory T Cell Development and Homeostasis.

Owen DL, Mahmud SA, Vang KB, Kelly RM, Blazar BR, Smith KA, Farrar MA. Owen DL, et al. Among authors: smith ka. J Immunol. 2018 Jun 15;200(12):3926-3933. doi: 10.4049/jimmunol.1800097. Epub 2018 May 4. J Immunol. 2018. PMID: 29728511 Free PMC article.

10

Brain-wide cell-type-specific transcriptomic signatures of healthy ageing in mice.

Jin K, Yao Z, van Velthoven CTJ, Kaplan ES, Glattfelder K, Barlow ST, Boyer G, Carey D, Casper T, Chakka AB, Chakrabarty R, Clark M, Departee M, Desierto M, Gary A, Gloe J, Goldy J, Guilford N, Guzman J, Hirschstein D, Lee C, Liang E, Pham T, Reding M, Ronellenfitch K, Ruiz A, Sevigny J, Shapovalova N, Shulga L, Sulc J, Torkelson A, Tung H, Levi B, Sunkin SM, Dee N, Esposito L, Smith KA, Tasic B, Zeng H. Jin K, et al. Among authors: smith ka. Nature. 2025 Jan 1. doi: 10.1038/s41586-024-08350-8. Online ahead of print. Nature. 2025. PMID: 39743592

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