McMahon M - Search Results

1

Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression.

McMahon M, Itoh K, Yamamoto M, Hayes JD. McMahon M, et al. J Biol Chem. 2003 Jun 13;278(24):21592-600. doi: 10.1074/jbc.M300931200. Epub 2003 Apr 7. J Biol Chem. 2003. PMID: 12682069 Free article.

2

The Nrf2 transcription factor contributes both to the basal expression of glutathione S-transferases in mouse liver and to their induction by the chemopreventive synthetic antioxidants, butylated hydroxyanisole and ethoxyquin.

Hayes JD, Chanas SA, Henderson CJ, McMahon M, Sun C, Moffat GJ, Wolf CR, Yamamoto M. Hayes JD, et al. Among authors: mcmahon m. Biochem Soc Trans. 2000 Feb;28(2):33-41. doi: 10.1042/bst0280033. Biochem Soc Trans. 2000. PMID: 10816095

3

The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes.

McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, Wolf CR, Cavin C, Hayes JD. McMahon M, et al. Cancer Res. 2001 Apr 15;61(8):3299-307. Cancer Res. 2001. PMID: 11309284

4

Reduction of aflatoxin B1 dialdehyde by rat and human aldo-keto reductases.

Guengerich FP, Cai H, McMahon M, Hayes JD, Sutter TR, Groopman JD, Deng Z, Harris TM. Guengerich FP, et al. Among authors: mcmahon m. Chem Res Toxicol. 2001 Jun;14(6):727-37. doi: 10.1021/tx010005p. Chem Res Toxicol. 2001. PMID: 11409944

5

Molecular basis for the contribution of the antioxidant responsive element to cancer chemoprevention.

Hayes JD, McMahon M. Hayes JD, et al. Among authors: mcmahon m. Cancer Lett. 2001 Dec 28;174(2):103-13. doi: 10.1016/s0304-3835(01)00695-4. Cancer Lett. 2001. PMID: 11689285 Review.

6

Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and Gstm4 genes in the livers of male and female mice.

Chanas SA, Jiang Q, McMahon M, McWalter GK, McLellan LI, Elcombe CR, Henderson CJ, Wolf CR, Moffat GJ, Itoh K, Yamamoto M, Hayes JD. Chanas SA, et al. Among authors: mcmahon m. Biochem J. 2002 Jul 15;365(Pt 2):405-16. doi: 10.1042/BJ20020320. Biochem J. 2002. PMID: 11991805 Free PMC article.

7

Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD(P)H:quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence.

Nioi P, McMahon M, Itoh K, Yamamoto M, Hayes JD. Nioi P, et al. Among authors: mcmahon m. Biochem J. 2003 Sep 1;374(Pt 2):337-48. doi: 10.1042/BJ20030754. Biochem J. 2003. PMID: 12816537 Free PMC article.

8

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.

Goldring CE, Kitteringham NR, Elsby R, Randle LE, Clement YN, Williams DP, McMahon M, Hayes JD, Itoh K, Yamamoto M, Park BK. Goldring CE, et al. Among authors: mcmahon m. Hepatology. 2004 May;39(5):1267-76. doi: 10.1002/hep.20183. Hepatology. 2004. PMID: 15122755

9

Redox-regulated turnover of Nrf2 is determined by at least two separate protein domains, the redox-sensitive Neh2 degron and the redox-insensitive Neh6 degron.

McMahon M, Thomas N, Itoh K, Yamamoto M, Hayes JD. McMahon M, et al. J Biol Chem. 2004 Jul 23;279(30):31556-67. doi: 10.1074/jbc.M403061200. Epub 2004 May 13. J Biol Chem. 2004. PMID: 15143058 Free article.

10

Evolutionary conserved N-terminal domain of Nrf2 is essential for the Keap1-mediated degradation of the protein by proteasome.

Katoh Y, Iida K, Kang MI, Kobayashi A, Mizukami M, Tong KI, McMahon M, Hayes JD, Itoh K, Yamamoto M. Katoh Y, et al. Among authors: mcmahon m. Arch Biochem Biophys. 2005 Jan 15;433(2):342-50. doi: 10.1016/j.abb.2004.10.012. Arch Biochem Biophys. 2005. PMID: 15581590 Review.

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