Klingler O - Search Results

1

Design, synthesis, and structure-activity relationship of a new class of amidinophenylurea-based factor VIIa inhibitors.

Klingler O, Matter H, Schudok M, Bajaj SP, Czech J, Lorenz M, Nestler HP, Schreuder H, Wildgoose P. Klingler O, et al. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1463-7. doi: 10.1016/s0960-894x(03)00168-9. Bioorg Med Chem Lett. 2003. PMID: 12668013

2

Novel factor Xa inhibitors based on a benzoic acid scaffold and incorporating a neutral P1 ligand.

Nazaré M, Matter H, Klingler O, Al-Obeidi F, Schreuder H, Zoller G, Czech J, Lorenz M, Dudda A, Peyman A, Nestler HP, Urmann M, Bauer A, Laux V, Wehner V, Will DW. Nazaré M, et al. Among authors: klingler o. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2801-5. doi: 10.1016/j.bmcl.2004.03.059. Bioorg Med Chem Lett. 2004. PMID: 15125936

3

Structure-based design of amidinophenylurea-derivatives for factor VIIa inhibition.

Klingler O, Matter H, Schudok M, Donghi M, Czech J, Lorenz M, Nestler HP, Szillat H, Schreuder H. Klingler O, et al. Bioorg Med Chem Lett. 2004 Jul 16;14(14):3715-20. doi: 10.1016/j.bmcl.2004.05.006. Bioorg Med Chem Lett. 2004. PMID: 15203149

4

Structural requirements for inhibition of the neuronal nitric oxide synthase (NOS-I): 3D-QSAR analysis of 4-oxo- and 4-amino-pteridine-based inhibitors.

Matter H, Kotsonis P, Klingler O, Strobel H, Fröhlich LG, Frey A, Pfleiderer W, Schmidt HH. Matter H, et al. Among authors: klingler o. J Med Chem. 2002 Jul 4;45(14):2923-41. doi: 10.1021/jm020074g. J Med Chem. 2002. PMID: 12086480

5

Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold.

Stilz HU, Guba W, Jablonka B, Just M, Klingler O, König W, Wehner V, Zoller G. Stilz HU, et al. Among authors: klingler o. J Med Chem. 2001 Apr 12;44(8):1158-76. doi: 10.1021/jm001068s. J Med Chem. 2001. PMID: 11312916

6

Structural basis for the highly selective inhibition of MMP-13.

Engel CK, Pirard B, Schimanski S, Kirsch R, Habermann J, Klingler O, Schlotte V, Weithmann KU, Wendt KU. Engel CK, et al. Among authors: klingler o. Chem Biol. 2005 Feb;12(2):181-9. doi: 10.1016/j.chembiol.2004.11.014. Chem Biol. 2005. PMID: 15734645

7

Freezing Time Prediction of Biologic Formulated Drug Substance Using the Plank Model.

Nakach M, Bahloul F, Greco S, Authelin JR, Klingler O, Bernhardt C. Nakach M, et al. Among authors: klingler o. PDA J Pharm Sci Technol. 2021 Jan-Feb;75(1):24-32. doi: 10.5731/pdajpst.2019.011247. Epub 2020 Aug 14. PDA J Pharm Sci Technol. 2021. PMID: 32817319

8

Moving to CoPACaPAnA: Implementation of a continuous protein A capture process for antibody applications within an end-to-end single-use GMP manufacturing downstream process.

Ötes O, Bernhardt C, Brandt K, Flato H, Klingler O, Landrock K, Lohr V, Stähler R, Capito F. Ötes O, et al. Among authors: klingler o. Biotechnol Rep (Amst). 2020 May 4;26:e00465. doi: 10.1016/j.btre.2020.e00465. eCollection 2020 Jun. Biotechnol Rep (Amst). 2020. PMID: 32420053 Free PMC article.

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