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Page 1
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: nakai h. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4. doi: 10.1016/s0960-894x(02)00455-9. Bioorg Med Chem Lett. 2002. PMID: 12161118
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines.
Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Nishizaki M, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: nakai h. Bioorg Med Chem. 2003 Mar 6;11(5):689-702. doi: 10.1016/s0968-0896(02)00540-0. Bioorg Med Chem. 2003. PMID: 12537998
Discovery of orally active prostaglandin D2 receptor antagonists.
Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: nakai y, nakai h. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4891-5. doi: 10.1016/j.bmcl.2004.07.039. Bioorg Med Chem Lett. 2004. PMID: 15341946
Discovery of heteroaryl sulfonamides as new EP1 receptor selective antagonists.
Naganawa A, Matsui T, Saito T, Ima M, Tatsumi T, Yamamoto S, Murota M, Yamamoto H, Maruyama T, Ohuchida S, Nakai H, Kondo K, Toda M. Naganawa A, et al. Among authors: nakai h. Bioorg Med Chem. 2006 Oct 1;14(19):6628-39. doi: 10.1016/j.bmc.2006.05.076. Epub 2006 Jun 19. Bioorg Med Chem. 2006. PMID: 16784865
Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.
Nishizawa R, Nishiyama T, Hisaichi K, Hirai K, Habashita H, Takaoka Y, Tada H, Sagawa K, Shibayama S, Maeda K, Mitsuya H, Nakai H, Fukushima D, Toda M. Nishizawa R, et al. Among authors: nakai h. Bioorg Med Chem. 2010 Jul 15;18(14):5208-23. doi: 10.1016/j.bmc.2010.05.057. Epub 2010 May 25. Bioorg Med Chem. 2010. PMID: 20542438 Free PMC article.
Discovery of 4-[4-({(3R)-1-butyl-3-[(R)-cyclohexyl(hydroxy)methyl]-2,5-dioxo-1,4,9-triazaspiro[5.5]undec-9-yl}methyl)phenoxy]benzoic acid hydrochloride: a highly potent orally available CCR5 selective antagonist.
Nishizawa R, Nishiyama T, Hisaichi K, Minamoto C, Murota M, Takaoka Y, Nakai H, Tada H, Sagawa K, Shibayama S, Fukushima D, Maeda K, Mitsuya H. Nishizawa R, et al. Among authors: nakai h. Bioorg Med Chem. 2011 Jul 1;19(13):4028-42. doi: 10.1016/j.bmc.2011.05.022. Epub 2011 May 20. Bioorg Med Chem. 2011. PMID: 21658961 Free PMC article.
1,183 results