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Critical role of the FERM domain in Pyk2 stimulated glioma cell migration.
Lipinski CA, Tran NL, Dooley A, Pang YP, Rohl C, Kloss J, Yang Z, McDonough W, Craig D, Berens ME, Loftus JC. Lipinski CA, et al. Among authors: loftus jc. Biochem Biophys Res Commun. 2006 Oct 27;349(3):939-47. doi: 10.1016/j.bbrc.2006.08.134. Epub 2006 Aug 31. Biochem Biophys Res Commun. 2006. PMID: 16962067
Increased fibroblast growth factor-inducible 14 expression levels promote glioma cell invasion via Rac1 and nuclear factor-kappaB and correlate with poor patient outcome.
Tran NL, McDonough WS, Savitch BA, Fortin SP, Winkles JA, Symons M, Nakada M, Cunliffe HE, Hostetter G, Hoelzinger DB, Rennert JL, Michaelson JS, Burkly LC, Lipinski CA, Loftus JC, Mariani L, Berens ME. Tran NL, et al. Among authors: loftus jc. Cancer Res. 2006 Oct 1;66(19):9535-42. doi: 10.1158/0008-5472.CAN-06-0418. Cancer Res. 2006. PMID: 17018610
Extended survival of Pyk2 or FAK deficient orthotopic glioma xenografts.
Lipinski CA, Tran NL, Viso C, Kloss J, Yang Z, Berens ME, Loftus JC. Lipinski CA, et al. Among authors: loftus jc. J Neurooncol. 2008 Nov;90(2):181-9. doi: 10.1007/s11060-008-9656-8. Epub 2008 Jul 22. J Neurooncol. 2008. PMID: 18648907 Free PMC article.
The Pyk2 FERM domain as a target to inhibit glioma migration.
Loftus JC, Yang Z, Tran NL, Kloss J, Viso C, Berens ME, Lipinski CA. Loftus JC, et al. Mol Cancer Ther. 2009 Jun;8(6):1505-14. doi: 10.1158/1535-7163.MCT-08-1055. Epub 2009 Jun 9. Mol Cancer Ther. 2009. PMID: 19509258 Free PMC article.
Targeting Pyk2 for therapeutic intervention.
Lipinski CA, Loftus JC. Lipinski CA, et al. Among authors: loftus jc. Expert Opin Ther Targets. 2010 Jan;14(1):95-108. doi: 10.1517/14728220903473194. Expert Opin Ther Targets. 2010. PMID: 20001213 Free PMC article. Review.
101 results