Elsby R - Search Results

1

Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.

Elsby R, Kitteringham NR, Goldring CE, Lovatt CA, Chamberlain M, Henderson CJ, Wolf CR, Park BK. Elsby R, et al. J Biol Chem. 2003 Jun 20;278(25):22243-9. doi: 10.1074/jbc.M301211200. Epub 2003 Mar 19. J Biol Chem. 2003. PMID: 12646564 Free article.

2

Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver.

Kitteringham NR, Powell H, Jenkins RE, Hamlett J, Lovatt C, Elsby R, Henderson CJ, Wolf CR, Pennington SR, Park BK. Kitteringham NR, et al. Among authors: elsby r. Proteomics. 2003 Feb;3(2):191-207. doi: 10.1002/pmic.200390028. Proteomics. 2003. PMID: 12601812

3

Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.

Goldring CE, Kitteringham NR, Elsby R, Randle LE, Clement YN, Williams DP, McMahon M, Hayes JD, Itoh K, Yamamoto M, Park BK. Goldring CE, et al. Among authors: elsby r. Hepatology. 2004 May;39(5):1267-76. doi: 10.1002/hep.20183. Hepatology. 2004. PMID: 15122755

4

Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags.

Jenkins RE, Kitteringham NR, Hunter CL, Webb S, Hunt TJ, Elsby R, Watson RB, Williams D, Pennington SR, Park BK. Jenkins RE, et al. Among authors: elsby r. Proteomics. 2006 Mar;6(6):1934-47. doi: 10.1002/pmic.200500432. Proteomics. 2006. PMID: 16479536

5

Comparison of the modulatory effects of human and rat liver microsomal metabolism on the estrogenicity of bisphenol A: implications for extrapolation to humans.

Elsby R, Maggs JL, Ashby J, Park BK. Elsby R, et al. J Pharmacol Exp Ther. 2001 Apr;297(1):103-13. J Pharmacol Exp Ther. 2001. PMID: 11259533

6

Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay.

Elsby R, Maggs JL, Ashby J, Paton D, Sumpter JP, Park BK. Elsby R, et al. J Pharmacol Exp Ther. 2001 Feb;296(2):329-37. J Pharmacol Exp Ther. 2001. PMID: 11160614

7

Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor.

Elsby R, Ashby J, Sumpter JP, Brooks AN, Pennie WD, Maggs JL, Lefevre PA, Odum J, Beresford N, Paton D, Park BK. Elsby R, et al. Biochem Pharmacol. 2000 Nov 15;60(10):1519-30. doi: 10.1016/s0006-2952(00)00466-4. Biochem Pharmacol. 2000. PMID: 11020455

8

Intracellular drug concentrations and transporters: measurement, modeling, and implications for the liver.

Chu X, Korzekwa K, Elsby R, Fenner K, Galetin A, Lai Y, Matsson P, Moss A, Nagar S, Rosania GR, Bai JP, Polli JW, Sugiyama Y, Brouwer KL; International Transporter Consortium. Chu X, et al. Among authors: elsby r. Clin Pharmacol Ther. 2013 Jul;94(1):126-41. doi: 10.1038/clpt.2013.78. Epub 2013 Apr 10. Clin Pharmacol Ther. 2013. PMID: 23588320 Free PMC article. Review.

9

Understanding the critical disposition pathways of statins to assess drug-drug interaction risk during drug development: it's not just about OATP1B1.

Elsby R, Hilgendorf C, Fenner K. Elsby R, et al. Clin Pharmacol Ther. 2012 Nov;92(5):584-98. doi: 10.1038/clpt.2012.163. Epub 2012 Oct 10. Clin Pharmacol Ther. 2012. PMID: 23047648 Review.

10

The use of bioreactors as in vitro models in pharmaceutical research.

Ginai M, Elsby R, Hewitt CJ, Surry D, Fenner K, Coopman K. Ginai M, et al. Among authors: elsby r. Drug Discov Today. 2013 Oct;18(19-20):922-35. doi: 10.1016/j.drudis.2013.05.016. Epub 2013 Jun 5. Drug Discov Today. 2013. PMID: 23748137 Review.

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