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Aficamten is a small-molecule cardiac myosin inhibitor designed to treat hypertrophic cardiomyopathy.
Hartman JJ, Hwee DT, Robert-Paganin J, Chuang C, Chin ER, Edell S, Lee KH, Madhvani R, Paliwal P, Pernier J, Sarkar SS, Schaletzky J, Schauer K, Taheri KD, Wang J, Wehri E, Wu Y, Houdusse A, Morgan BP, Malik FI. Hartman JJ, et al. Among authors: schaletzky j. Nat Cardiovasc Res. 2024 Aug;3(8):1003-1016. doi: 10.1038/s44161-024-00505-0. Epub 2024 Jul 23. Nat Cardiovasc Res. 2024. PMID: 39196032 Free PMC article.
Mercapto-pyrimidines are reversible covalent inhibitors of the papain-like protease (PLpro) and inhibit SARS-CoV-2 (SCoV-2) replication.
Bajaj T, Wehri E, Suryawanshi RK, King E, Pardeshi KS, Behrouzi K, Khodabakhshi Z, Schulze-Gahmen U, Kumar GR, Mofrad MRK, Nomura DK, Ott M, Schaletzky J, Murthy N. Bajaj T, et al. Among authors: schaletzky j. RSC Adv. 2023 Jun 12;13(26):17667-17677. doi: 10.1039/d3ra01915b. eCollection 2023 Jun 9. RSC Adv. 2023. PMID: 37312993 Free PMC article.
Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis.
Hendricks JM, Doubravsky CE, Wehri E, Li Z, Roberts MA, Deol KK, Lange M, Lasheras-Otero I, Momper JD, Dixon SJ, Bersuker K, Schaletzky J, Olzmann JA. Hendricks JM, et al. Among authors: schaletzky j. Cell Chem Biol. 2023 Sep 21;30(9):1090-1103.e7. doi: 10.1016/j.chembiol.2023.04.007. Epub 2023 May 12. Cell Chem Biol. 2023. PMID: 37178691 Free PMC article.
24 results