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Page 1
Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase.
Achan V, Broadhead M, Malaki M, Whitley G, Leiper J, MacAllister R, Vallance P. Achan V, et al. Among authors: vallance p. Arterioscler Thromb Vasc Biol. 2003 Aug 1;23(8):1455-9. doi: 10.1161/01.ATV.0000081742.92006.59. Epub 2003 Jun 12. Arterioscler Thromb Vasc Biol. 2003. PMID: 12805079 Clinical Trial.
The DDAH/ADMA/NOS pathway.
Tran CT, Leiper JM, Vallance P. Tran CT, et al. Among authors: vallance p. Atheroscler Suppl. 2003 Dec;4(4):33-40. doi: 10.1016/s1567-5688(03)00032-1. Atheroscler Suppl. 2003. PMID: 14664901 Review.
Pulmonary hypertension in a GTP-cyclohydrolase 1-deficient mouse.
Nandi M, Miller A, Stidwill R, Jacques TS, Lam AA, Haworth S, Heales S, Vallance P. Nandi M, et al. Among authors: vallance p. Circulation. 2005 Apr 26;111(16):2086-90. doi: 10.1161/01.CIR.0000163268.32638.F4. Epub 2005 Apr 11. Circulation. 2005. PMID: 15824199
S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: further interactions between nitric oxide synthase and dimethylarginine dimethylaminohydrolase.
Leiper J, Murray-Rust J, McDonald N, Vallance P. Leiper J, et al. Among authors: vallance p. Proc Natl Acad Sci U S A. 2002 Oct 15;99(21):13527-32. doi: 10.1073/pnas.212269799. Epub 2002 Oct 7. Proc Natl Acad Sci U S A. 2002. PMID: 12370443 Free PMC article.
M., McAlister, M., Phelan, J., Tilley, S., Santa Maria, J., Vallance, P. & McDonald, N. (2001) Nat. Struct. Biol. 8, 679-683]. The presence of a reactive cysteine residue (Cys-249) in the active site of DDAH raised the possibility that DDAH activity might be dir …
M., McAlister, M., Phelan, J., Tilley, S., Santa Maria, J., Vallance, P. & McDonald, N. (2001) Nat. Struct. Biol. 8, 679-6 …
268 results