Laufer R - Search Results

1

Construction of an rtTA2(s)-m2/tts(kid)-based transcription regulatory switch that displays no basal activity, good inducibility, and high responsiveness to doxycycline in mice and non-human primates.

Lamartina S, Silvi L, Roscilli G, Casimiro D, Simon AJ, Davies ME, Shiver JW, Rinaudo CD, Zampaglione I, Fattori E, Colloca S, Gonzalez Paz O, Laufer R, Bujard H, Cortese R, Ciliberto G, Toniatti C. Lamartina S, et al. Among authors: laufer r. Mol Ther. 2003 Feb;7(2):271-80. doi: 10.1016/s1525-0016(02)00051-5. Mol Ther. 2003. PMID: 12597916 Free article.

2

A structure-guided approach to an orthogonal estrogen-receptor-based gene switch activated by ligands suitable for in vivo studies.

Kinzel O, Fattori D, Muraglia E, Gallinari P, Nardi MC, Paolini C, Roscilli G, Toniatti C, Gonzalez Paz O, Laufer R, Lahm A, Tramontano A, Cortese R, De Francesco R, Ciliberto G, Koch U. Kinzel O, et al. Among authors: laufer r. J Med Chem. 2006 Sep 7;49(18):5404-7. doi: 10.1021/jm060516e. J Med Chem. 2006. PMID: 16942012

3

Efficient and regulated erythropoietin production by naked DNA injection and muscle electroporation.

Rizzuto G, Cappelletti M, Maione D, Savino R, Lazzaro D, Costa P, Mathiesen I, Cortese R, Ciliberto G, Laufer R, La Monica N, Fattori E. Rizzuto G, et al. Among authors: laufer r. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6417-22. doi: 10.1073/pnas.96.11.6417. Proc Natl Acad Sci U S A. 1999. PMID: 10339602 Free PMC article.

4

Enhancing B- and T-cell immune response to a hepatitis C virus E2 DNA vaccine by intramuscular electrical gene transfer.

Zucchelli S, Capone S, Fattori E, Folgori A, Di Marco A, Casimiro D, Simon AJ, Laufer R, La Monica N, Cortese R, Nicosia A. Zucchelli S, et al. Among authors: laufer r. J Virol. 2000 Dec;74(24):11598-607. doi: 10.1128/jvi.74.24.11598-11607.2000. J Virol. 2000. PMID: 11090158 Free PMC article.

5

Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance.

Gloaguen I, Costa P, Demartis A, Lazzaro D, Di Marco A, Graziani R, Paonessa G, Chen F, Rosenblum CI, Van der Ploeg LH, Cortese R, Ciliberto G, Laufer R. Gloaguen I, et al. Among authors: laufer r. Proc Natl Acad Sci U S A. 1997 Jun 10;94(12):6456-61. doi: 10.1073/pnas.94.12.6456. Proc Natl Acad Sci U S A. 1997. PMID: 9177239 Free PMC article.

6

Dihydroxypyrimidine-4-carboxamides as novel potent and selective HIV integrase inhibitors.

Pace P, Di Francesco ME, Gardelli C, Harper S, Muraglia E, Nizi E, Orvieto F, Petrocchi A, Poma M, Rowley M, Scarpelli R, Laufer R, Gonzalez Paz O, Monteagudo E, Bonelli F, Hazuda D, Stillmock KA, Summa V. Pace P, et al. Among authors: laufer r. J Med Chem. 2007 May 3;50(9):2225-39. doi: 10.1021/jm070027u. Epub 2007 Apr 12. J Med Chem. 2007. PMID: 17428043

7

Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.

Muraglia E, Kinzel O, Gardelli C, Crescenzi B, Donghi M, Ferrara M, Nizi E, Orvieto F, Pescatore G, Laufer R, Gonzalez-Paz O, Di Marco A, Fiore F, Monteagudo E, Fonsi M, Felock PJ, Rowley M, Summa V. Muraglia E, et al. Among authors: laufer r. J Med Chem. 2008 Feb 28;51(4):861-74. doi: 10.1021/jm701164t. Epub 2008 Jan 25. J Med Chem. 2008. PMID: 18217703

8

Cyclic phosphoramidates as prodrugs of 2'-C-methylcytidine.

Meppen M, Pacini B, Bazzo R, Koch U, Leone JF, Koeplinger KA, Rowley M, Altamura S, Di Marco A, Fiore F, Giuliano C, Gonzalez-Paz O, Laufer R, Pucci V, Narjes F, Gardelli C. Meppen M, et al. Among authors: laufer r. Eur J Med Chem. 2009 Sep;44(9):3765-70. doi: 10.1016/j.ejmech.2009.04.043. Epub 2009 May 8. Eur J Med Chem. 2009. PMID: 19493593

9

SAR and pharmacokinetic studies on phenethylamide inhibitors of the hepatitis C virus NS3/NS4A serine protease.

Malancona S, Colarusso S, Ontoria JM, Marchetti A, Poma M, Stansfield I, Laufer R, Di Marco A, Taliani M, Verdirame M, Gonzalez-Paz O, Matassa VG, Narjes F. Malancona S, et al. Among authors: laufer r. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4575-9. doi: 10.1016/j.bmcl.2004.05.093. Bioorg Med Chem Lett. 2004. PMID: 15357995

10

In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex.

De Serio A, Graziani R, Laufer R, Ciliberto G, Paonessa G. De Serio A, et al. Among authors: laufer r. J Mol Biol. 1995 Dec 15;254(5):795-800. doi: 10.1006/jmbi.1995.0655. J Mol Biol. 1995. PMID: 7500350

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