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A methylated phosphate group and four amide-linked acyl chains in leptospira interrogans lipid A. The membrane anchor of an unusual lipopolysaccharide that activates TLR2.
Que-Gewirth NL, Ribeiro AA, Kalb SR, Cotter RJ, Bulach DM, Adler B, Girons IS, Werts C, Raetz CR. Que-Gewirth NL, et al. Among authors: raetz cr. J Biol Chem. 2004 Jun 11;279(24):25420-9. doi: 10.1074/jbc.M400598200. Epub 2004 Mar 24. J Biol Chem. 2004. PMID: 15044492 Free PMC article.
Enzymatic synthesis of lipid A molecules with four amide-linked acyl chains. LpxA acyltransferases selective for an analog of UDP-N-acetylglucosamine in which an amine replaces the 3"-hydroxyl group.
Sweet CR, Williams AH, Karbarz MJ, Werts C, Kalb SR, Cotter RJ, Raetz CR. Sweet CR, et al. Among authors: raetz cr. J Biol Chem. 2004 Jun 11;279(24):25411-9. doi: 10.1074/jbc.M400597200. Epub 2004 Mar 24. J Biol Chem. 2004. PMID: 15044493 Free PMC article.
317 results