Zhang H - Search Results

1

Mutation of tyrosine 190 to alanine eliminates the inactivation of cytochrome P450 2B1 by peroxynitrite.

Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF. Lin HL, et al. Among authors: zhang h. Chem Res Toxicol. 2003 Feb;16(2):129-36. doi: 10.1021/tx020040b. Chem Res Toxicol. 2003. PMID: 12588183

2

Threonine-205 in the F helix of p450 2B1 contributes to androgen 16 beta-hydroxylation activity and mechanism-based inactivation.

Lin HL, Zhang H, Waskell L, Hollenberg PF. Lin HL, et al. Among authors: zhang h. J Pharmacol Exp Ther. 2003 Aug;306(2):744-51. doi: 10.1124/jpet.103.050260. Epub 2003 Apr 29. J Pharmacol Exp Ther. 2003. PMID: 12721329

3

Preparation and characterization of a 5'-deazaFAD T491V NADPH-cytochrome P450 reductase.

Zhang H, Gruenke L, Saribas AS, Im SC, Shen AL, Kasper CB, Waskell L. Zhang H, et al. Biochemistry. 2003 Jun 10;42(22):6804-13. doi: 10.1021/bi030081m. Biochemistry. 2003. PMID: 12779335

4

Determination of the rate of reduction of oxyferrous cytochrome P450 2B4 by 5-deazariboflavin adenine dinucleotide T491V cytochrome P450 reductase.

Zhang H, Gruenke L, Arscott D, Shen A, Kasper C, Harris DL, Glavanovich M, Johnson R, Waskell L. Zhang H, et al. Biochemistry. 2003 Oct 14;42(40):11594-603. doi: 10.1021/bi034968u. Biochemistry. 2003. PMID: 14529269

In this reductase the FMN moiety can be reduced to the hydroquinone, FMNH(2), while the 5-deazaFAD moiety remains oxidized [Zhang, H., et al. (2003) Biochemistry 42, 6804-6813]. The rate of electron transfer from 5-deazaFAD cyt P450 reductase to oxyferrous cyt P450 …

In this reductase the FMN moiety can be reduced to the hydroquinone, FMNH(2), while the 5-deazaFAD moiety remains oxidized [Zhang, …

5

The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis.

Lin HL, Kent UM, Zhang H, Waskell L, Hollenberg PF. Lin HL, et al. Among authors: zhang h. J Pharmacol Exp Ther. 2004 Dec;311(3):855-63. doi: 10.1124/jpet.104.071670. Epub 2004 Aug 9. J Pharmacol Exp Ther. 2004. PMID: 15302894

6

The highly conserved Glu149 and Tyr190 residues contribute to peroxynitrite-mediated nitrotyrosine formation and the catalytic activity of cytochrome P450 2B1.

Lin HL, Zhang H, Waskell L, Hollenberg PF. Lin HL, et al. Among authors: zhang h. Chem Res Toxicol. 2005 Aug;18(8):1203-10. doi: 10.1021/tx050100o. Chem Res Toxicol. 2005. PMID: 16097793

7

Role of cytochrome b5 in catalysis by cytochrome P450 2B4.

Zhang H, Myshkin E, Waskell L. Zhang H, et al. Biochem Biophys Res Commun. 2005 Dec 9;338(1):499-506. doi: 10.1016/j.bbrc.2005.09.022. Epub 2005 Sep 15. Biochem Biophys Res Commun. 2005. PMID: 16182240 Review.

8

Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines.

Kobayashi Y, Sridar C, Kent UM, Puppali SG, Rimoldi JM, Zhang H, Waskell L, Hollenberg PF. Kobayashi Y, et al. Among authors: zhang h. Drug Metab Dispos. 2006 Dec;34(12):2102-10. doi: 10.1124/dmd.106.011452. Epub 2006 Sep 22. Drug Metab Dispos. 2006. PMID: 16997911

9

Cytochrome b5 increases the rate of product formation by cytochrome P450 2B4 and competes with cytochrome P450 reductase for a binding site on cytochrome P450 2B4.

Zhang H, Im SC, Waskell L. Zhang H, et al. J Biol Chem. 2007 Oct 12;282(41):29766-76. doi: 10.1074/jbc.M703845200. Epub 2007 Aug 10. J Biol Chem. 2007. PMID: 17693640 Free article.

10

Cytochrome b5 inhibits electron transfer from NADPH-cytochrome P450 reductase to ferric cytochrome P450 2B4.

Zhang H, Hamdane D, Im SC, Waskell L. Zhang H, et al. J Biol Chem. 2008 Feb 29;283(9):5217-25. doi: 10.1074/jbc.M709094200. Epub 2007 Dec 17. J Biol Chem. 2008. PMID: 18086668 Free article.

Experiments demonstrating that cytochrome (cyt) b5 inhibits the activity of cytochrome P450 2B4 (cyt P450 2B4) at higher concentrations suggested that cyt b5 was occupying the cyt P450 reductase-binding site on cyt P450 2B4 and preventing the reduction of ferric cyt P450 (Zhan …

Experiments demonstrating that cytochrome (cyt) b5 inhibits the activity of cytochrome P450 2B4 (cyt P450 2B4) at higher concentrations sugg …

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