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A novel inhibitor of oxidosqualene:lanosterol cyclase inhibits very low-density lipoprotein apolipoprotein B100 (apoB100) production and enhances low-density lipoprotein apoB100 catabolism through marked reduction in hepatic cholesterol content.
Telford DE, Lipson SM, Barrett PH, Sutherland BG, Edwards JY, Aebi JD, Dehmlow H, Morand OH, Huff MW. Telford DE, et al. Among authors: edwards jy. Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2608-14. doi: 10.1161/01.ATV.0000189158.28455.94. Epub 2005 Oct 6. Arterioscler Thromb Vasc Biol. 2005. PMID: 16210564
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