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Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines.
Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Nishizaki M, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: komeno m. Bioorg Med Chem. 2003 Mar 6;11(5):689-702. doi: 10.1016/s0968-0896(02)00540-0. Bioorg Med Chem. 2003. PMID: 12537998
Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.
Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: komeno m. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4. doi: 10.1016/s0960-894x(02)00455-9. Bioorg Med Chem Lett. 2002. PMID: 12161118
Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases.
Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Komiya T, Hagiya H, Mizuno H, Shioya H, Ono T, Takada Y, Maeda T, Matsunaga N, Kondo T, Tominaga S, Nunoya KI, Kiyoshi H, Komeno M, Nakade S, Habashita H. Kurata H, et al. Among authors: komeno m. J Med Chem. 2017 Dec 14;60(23):9508-9530. doi: 10.1021/acs.jmedchem.7b00785. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29120624
QT PRODACT: evaluation of the potential of compounds to cause QT interval prolongation by action potential assays using guinea-pig papillary muscles.
Kii Y, Hayashi S, Tabo M, Shimosato T, Fukuda H, Itoh T, Amano H, Saito M, Morimoto H, Yamada K, Kanda A, Ishitsuka T, Yamazaki T, Kiuchi Y, Taniguchi S, Mori T, Shimizu S, Tsurubuchi Y, Yasuda S, Kitani S, Shimada C, Kobayashi K, Komeno M, Kasai C, Hombo T, Yamamoto K. Kii Y, et al. Among authors: komeno m. J Pharmacol Sci. 2005;99(5):449-57. doi: 10.1254/jphs.qt-c8. J Pharmacol Sci. 2005. PMID: 16493186 Free article.
QT PRODACT: a multi-site study of in vitro action potential assays on 21 compounds in isolated guinea-pig papillary muscles.
Hayashi S, Kii Y, Tabo M, Fukuda H, Itoh T, Shimosato T, Amano H, Saito M, Morimoto H, Yamada K, Kanda A, Ishitsuka T, Yamazaki T, Kiuchi Y, Taniguchi S, Mori T, Shimizu S, Tsurubuchi Y, Yasuda S, Kitani S, Shimada C, Kobayashi K, Komeno M, Kasai C, Hombo T, Yamamoto K. Hayashi S, et al. Among authors: komeno m. J Pharmacol Sci. 2005;99(5):423-37. doi: 10.1254/jphs.qt-a1. J Pharmacol Sci. 2005. PMID: 16493184 Free article.
31 results