Kobayashi K - Search Results

1

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. synthesis and biological evaluation of dihydropyridin-2(1H)-imines and 1,5,6,7-tetrahydro-2H-azepin-2-imines.

Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Nishizaki M, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: kobayashi k. Bioorg Med Chem. 2003 Mar 6;11(5):689-702. doi: 10.1016/s0968-0896(02)00540-0. Bioorg Med Chem. 2003. PMID: 12537998

2

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Part 1: synthesis and biological evaluation of dihydropyridin-2-imines.

Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: kobayashi k. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2291-4. doi: 10.1016/s0960-894x(02)00455-9. Bioorg Med Chem Lett. 2002. PMID: 12161118

3

Design and synthesis of orally bioavailable inhibitors of inducible nitric oxide synthase. Identification of 2-azabicyclo[4.1.0]heptan-3-imines.

Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Odagaki Y, Nakai H, Toda M. Kawanaka Y, et al. Among authors: kobayashi k. Bioorg Med Chem. 2003 Apr 17;11(8):1723-43. doi: 10.1016/s0968-0896(03)00034-8. Bioorg Med Chem. 2003. PMID: 12659759

4

Design and synthesis of inhibitors of inducible nitric oxide synthase. Discovery of a new chemical lead with potential for oral bioavailability.

Kawanaka Y, Kobayashi K, Kusuda S, Tatsumi T, Murota M, Nishiyama T, Hisaichi K, Fujii A, Hirai K, Naka M, Komeno M, Nakai H, Toda M. Kawanaka Y, et al. Among authors: kobayashi k. Eur J Med Chem. 2003 Mar;38(3):277-88. doi: 10.1016/s0223-5234(03)00017-5. Eur J Med Chem. 2003. PMID: 12667694

5

Discovery of orally active prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: kobayashi k. Bioorg Med Chem Lett. 2004 Oct 4;14(19):4891-5. doi: 10.1016/j.bmcl.2004.07.039. Bioorg Med Chem Lett. 2004. PMID: 15341946

6

Design, synthesis, and biological evaluation of new phosphodiesterase type 4 inhibitors.

Ochiai H, Odagaki Y, Ohtani T, Ishida A, Kusumi K, Kishikawa K, Yamamoto S, Takeda H, Obata T, Kobayashi K, Nakai H, Toda M. Ochiai H, et al. Among authors: kobayashi k. Bioorg Med Chem. 2004 Oct 1;12(19):5063-78. doi: 10.1016/j.bmc.2004.07.040. Bioorg Med Chem. 2004. PMID: 15351390

7

Discovery of new chemical leads for prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Egashira H, Nakai Y, Okada Y, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: kobayashi k. Bioorg Med Chem Lett. 2004 Sep 6;14(17):4557-62. doi: 10.1016/j.bmcl.2004.06.006. Bioorg Med Chem Lett. 2004. PMID: 15357992

8

Development of prostaglandin D2 receptor antagonist: discovery of highly potent antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Masaaki Toda. Torisu K, et al. Among authors: kobayashi k. Bioorg Med Chem. 2004 Sep 1;12(17):4685-700. doi: 10.1016/j.bmc.2004.06.024. Bioorg Med Chem. 2004. PMID: 15358295

9

Discovery of a new class of potent, selective, and orally active prostaglandin D2 receptor antagonists.

Torisu K, Kobayashi K, Iwahashi M, Nakai Y, Onoda T, Nagase T, Sugimoto I, Okada Y, Matsumoto R, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: kobayashi k. Bioorg Med Chem. 2004 Oct 15;12(20):5361-78. doi: 10.1016/j.bmc.2004.07.048. Bioorg Med Chem. 2004. PMID: 15388164

10

Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead.

Torisu K, Kobayashi K, Iwahashi M, Egashira H, Nakai Y, Okada Y, Nanbu F, Ohuchida S, Nakai H, Toda M. Torisu K, et al. Among authors: kobayashi k. Eur J Med Chem. 2005 May;40(5):505-19. doi: 10.1016/j.ejmech.2004.11.011. Eur J Med Chem. 2005. PMID: 15893024

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