Begley M - Search Results

1

Crystal structure of an inactive Akt2 kinase domain.

Huang X, Begley M, Morgenstern KA, Gu Y, Rose P, Zhao H, Zhu X. Huang X, et al. Among authors: begley m. Structure. 2003 Jan;11(1):21-30. doi: 10.1016/s0969-2126(02)00937-1. Structure. 2003. PMID: 12517337 Free article.

2

Crystal structure of a phosphoinositide phosphatase, MTMR2: insights into myotubular myopathy and Charcot-Marie-Tooth syndrome.

Begley MJ, Taylor GS, Kim SA, Veine DM, Dixon JE, Stuckey JA. Begley MJ, et al. Mol Cell. 2003 Dec;12(6):1391-402. doi: 10.1016/s1097-2765(03)00486-6. Mol Cell. 2003. PMID: 14690594 Free article.

3

Autoinhibition and isoform-specific dominant negative inhibition of the type II cGMP-dependent protein kinase.

Taylor MK, Ahmed R, Begley M, Uhler MD. Taylor MK, et al. Among authors: begley m. J Biol Chem. 2002 Oct 4;277(40):37242-53. doi: 10.1074/jbc.M202060200. Epub 2002 Jul 1. J Biol Chem. 2002. PMID: 12093798 Free article.

4

The structure and regulation of myotubularin phosphatases.

Begley MJ, Dixon JE. Begley MJ, et al. Curr Opin Struct Biol. 2005 Dec;15(6):614-20. doi: 10.1016/j.sbi.2005.10.016. Epub 2005 Nov 9. Curr Opin Struct Biol. 2005. PMID: 16289848 Review.

5

Molecular basis for substrate recognition by MTMR2, a myotubularin family phosphoinositide phosphatase.

Begley MJ, Taylor GS, Brock MA, Ghosh P, Woods VL, Dixon JE. Begley MJ, et al. Proc Natl Acad Sci U S A. 2006 Jan 24;103(4):927-32. doi: 10.1073/pnas.0510006103. Epub 2006 Jan 12. Proc Natl Acad Sci U S A. 2006. PMID: 16410353 Free PMC article.

6

EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.

Begley MJ, Yun CH, Gewinner CA, Asara JM, Johnson JL, Coyle AJ, Eck MJ, Apostolou I, Cantley LC. Begley MJ, et al. Nat Struct Mol Biol. 2015 Dec;22(12):983-90. doi: 10.1038/nsmb.3117. Epub 2015 Nov 9. Nat Struct Mol Biol. 2015. PMID: 26551075 Free PMC article.

7

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations.

Woodroof HI, Pogson JH, Begley M, Cantley LC, Deak M, Campbell DG, van Aalten DM, Whitworth AJ, Alessi DR, Muqit MM. Woodroof HI, et al. Among authors: begley m. Open Biol. 2011 Nov;1(3):110012. doi: 10.1098/rsob.110012. Open Biol. 2011. PMID: 22645651 Free PMC article.

8

TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development.

Bouskila M, Esoof N, Gay L, Fang EH, Deak M, Begley MJ, Cantley LC, Prescott A, Storey KG, Alessi DR. Bouskila M, et al. Among authors: begley mj. Biochem J. 2011 Jul 1;437(1):157-67. doi: 10.1042/BJ20110276. Biochem J. 2011. PMID: 21548880 Free PMC article.

9

Death-associated protein kinase 1 phosphorylates NDRG2 and induces neuronal cell death.

You MH, Kim BM, Chen CH, Begley MJ, Cantley LC, Lee TH. You MH, et al. Cell Death Differ. 2017 Feb;24(2):238-250. doi: 10.1038/cdd.2016.114. Epub 2016 Nov 4. Cell Death Differ. 2017. PMID: 28141794 Free PMC article.

10

Mitotic MELK-eIF4B signaling controls protein synthesis and tumor cell survival.

Wang Y, Begley M, Li Q, Huang HT, Lako A, Eck MJ, Gray NS, Mitchison TJ, Cantley LC, Zhao JJ. Wang Y, et al. Among authors: begley m. Proc Natl Acad Sci U S A. 2016 Aug 30;113(35):9810-5. doi: 10.1073/pnas.1606862113. Epub 2016 Aug 15. Proc Natl Acad Sci U S A. 2016. PMID: 27528663 Free PMC article.

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