Watson MA - Search Results

1

Identification of bile acid precursors as endogenous ligands for the nuclear xenobiotic pregnane X receptor.

Goodwin B, Gauthier KC, Umetani M, Watson MA, Lochansky MI, Collins JL, Leitersdorf E, Mangelsdorf DJ, Kliewer SA, Repa JJ. Goodwin B, et al. Among authors: watson ma. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):223-8. doi: 10.1073/pnas.0237082100. Epub 2002 Dec 30. Proc Natl Acad Sci U S A. 2003. PMID: 12509506 Free PMC article.

2

The relative transcription index: a gene expression based metric for prioritization of drug candidates.

Ghosh S, Watson MA, Collins JL. Ghosh S, et al. Among authors: watson ma. Comb Chem High Throughput Screen. 2007 May;10(4):239-45. doi: 10.2174/138620707780636628. Comb Chem High Throughput Screen. 2007. PMID: 17506706

3

Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.

Goodwin B, Watson MA, Kim H, Miao J, Kemper JK, Kliewer SA. Goodwin B, et al. Among authors: watson ma. Mol Endocrinol. 2003 Mar;17(3):386-94. doi: 10.1210/me.2002-0246. Epub 2002 Dec 12. Mol Endocrinol. 2003. PMID: 12554795

4

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

Lehmann JM, McKee DD, Watson MA, Willson TM, Moore JT, Kliewer SA. Lehmann JM, et al. Among authors: watson ma. J Clin Invest. 1998 Sep 1;102(5):1016-23. doi: 10.1172/JCI3703. J Clin Invest. 1998. PMID: 9727070 Free PMC article.

5

A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis.

Goodwin B, Jones SA, Price RR, Watson MA, McKee DD, Moore LB, Galardi C, Wilson JG, Lewis MC, Roth ME, Maloney PR, Willson TM, Kliewer SA. Goodwin B, et al. Among authors: watson ma. Mol Cell. 2000 Sep;6(3):517-26. doi: 10.1016/s1097-2765(00)00051-4. Mol Cell. 2000. PMID: 11030332 Free article.

6

Liver X receptor (LXR) regulation of the LXRalpha gene in human macrophages.

Whitney KD, Watson MA, Goodwin B, Galardi CM, Maglich JM, Wilson JG, Willson TM, Collins JL, Kliewer SA. Whitney KD, et al. Among authors: watson ma. J Biol Chem. 2001 Nov 23;276(47):43509-15. doi: 10.1074/jbc.M106155200. Epub 2001 Aug 23. J Biol Chem. 2001. PMID: 11546778 Free article.

7

Synthetic LXR ligand inhibits the development of atherosclerosis in mice.

Joseph SB, McKilligin E, Pei L, Watson MA, Collins AR, Laffitte BA, Chen M, Noh G, Goodman J, Hagger GN, Tran J, Tippin TK, Wang X, Lusis AJ, Hsueh WA, Law RE, Collins JL, Willson TM, Tontonoz P. Joseph SB, et al. Among authors: watson ma. Proc Natl Acad Sci U S A. 2002 May 28;99(11):7604-9. doi: 10.1073/pnas.112059299. Proc Natl Acad Sci U S A. 2002. PMID: 12032330 Free PMC article.

8

Regulation of cholesterol homeostasis by the liver X receptors in the central nervous system.

Whitney KD, Watson MA, Collins JL, Benson WG, Stone TM, Numerick MJ, Tippin TK, Wilson JG, Winegar DA, Kliewer SA. Whitney KD, et al. Among authors: watson ma. Mol Endocrinol. 2002 Jun;16(6):1378-85. doi: 10.1210/mend.16.6.0835. Mol Endocrinol. 2002. PMID: 12040022

9

An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway.

Kliewer SA, Moore JT, Wade L, Staudinger JL, Watson MA, Jones SA, McKee DD, Oliver BB, Willson TM, Zetterström RH, Perlmann T, Lehmann JM. Kliewer SA, et al. Among authors: watson ma. Cell. 1998 Jan 9;92(1):73-82. doi: 10.1016/s0092-8674(00)80900-9. Cell. 1998. PMID: 9489701 Free article.

10

Structure-guided design of N-phenyl tertiary amines as transrepression-selective liver X receptor modulators with anti-inflammatory activity.

Chao EY, Caravella JA, Watson MA, Campobasso N, Ghisletti S, Billin AN, Galardi C, Wang P, Laffitte BA, Iannone MA, Goodwin BJ, Nichols JA, Parks DJ, Stewart E, Wiethe RW, Williams SP, Smallwood A, Pearce KH, Glass CK, Willson TM, Zuercher WJ, Collins JL. Chao EY, et al. Among authors: watson ma. J Med Chem. 2008 Sep 25;51(18):5758-65. doi: 10.1021/jm800612u. J Med Chem. 2008. PMID: 18800767

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