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Indolequinone antitumor agents: reductive activation and elimination from (5-methoxy-1-methyl-4,7-dioxoindol-3-yl)methyl derivatives and hypoxia-selective cytotoxicity in vitro.
Naylor MA, Swann E, Everett SA, Jaffar M, Nolan J, Robertson N, Lockyer SD, Patel KB, Dennis MF, Stratford MR, Wardman P, Adams GE, Moody CJ, Stratford IJ. Naylor MA, et al. Among authors: nolan j. J Med Chem. 1998 Jul 16;41(15):2720-31. doi: 10.1021/jm970744w. J Med Chem. 1998. PMID: 9667963
The relative importance of NADPH: cytochrome c (P450) reductase for determining the sensitivity of human tumour cells to the indolequinone EO9 and related analogues lacking functionality at the C-2 and C-3 positions.
Saunders MP, Jaffar M, Patterson AV, Nolan J, Naylor MA, Phillips RM, Harris AL, Stratford IJ. Saunders MP, et al. Among authors: nolan j. Biochem Pharmacol. 2000 Apr 15;59(8):993-6. doi: 10.1016/s0006-2952(99)00405-0. Biochem Pharmacol. 2000. PMID: 10692564
Radiolytic and photochemical reduction of the hypoxic cytotoxin 1,2-dihydro-8-(4-methylpiperazinyl)-4-phenylimidazo [1,2-a] pyrido [3,2-e] pyrazine 5-oxide (RB90740) and a potential mechanism for hypoxia-selective toxicity.
Naylor MA, Sutton BM, Nolan J, O'Neill P, Fielden EM, Adams GE, Stratford IJ. Naylor MA, et al. Among authors: nolan j. Int J Radiat Oncol Biol Phys. 1994 May 15;29(2):333-7. doi: 10.1016/0360-3016(94)90285-2. Int J Radiat Oncol Biol Phys. 1994. PMID: 8195029
1,872 results