Lynch DL - Search Results

1

Activation of the cannabinoid CB1 receptor may involve a W6 48/F3 36 rotamer toggle switch.

Singh R, Hurst DP, Barnett-Norris J, Lynch DL, Reggio PH, Guarnieri F. Singh R, et al. Among authors: lynch dl. J Pept Res. 2002 Dec;60(6):357-70. doi: 10.1034/j.1399-3011.2002.21065.x. J Pept Res. 2002. PMID: 12464114

2

Conformational memories and the endocannabinoid binding site at the cannabinoid CB1 receptor.

Barnett-Norris J, Hurst DP, Lynch DL, Guarnieri F, Makriyannis A, Reggio PH. Barnett-Norris J, et al. Among authors: lynch dl. J Med Chem. 2002 Aug 15;45(17):3649-59. doi: 10.1021/jm0200761. J Med Chem. 2002. PMID: 12166938

3

N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A) interaction with LYS 3.28(192) is crucial for its inverse agonism at the cannabinoid CB1 receptor.

Hurst DP, Lynch DL, Barnett-Norris J, Hyatt SM, Seltzman HH, Zhong M, Song ZH, Nie J, Lewis D, Reggio PH. Hurst DP, et al. Among authors: lynch dl. Mol Pharmacol. 2002 Dec;62(6):1274-87. doi: 10.1124/mol.62.6.1274. Mol Pharmacol. 2002. PMID: 12435794

4

Cannabinoid CB1 receptor recognition of endocannabinoids via the lipid bilayer: molecular dynamics simulations of CB1 transmembrane helix 6 and anandamide in a phospholipid bilayer.

Lynch DL, Reggio PH. Lynch DL, et al. J Comput Aided Mol Des. 2006 Jul-Aug;20(7-8):495-509. doi: 10.1007/s10822-006-9068-9. Epub 2006 Nov 14. J Comput Aided Mol Des. 2006. PMID: 17106765

5

Structural mimicry in class A G protein-coupled receptor rotamer toggle switches: the importance of the F3.36(201)/W6.48(357) interaction in cannabinoid CB1 receptor activation.

McAllister SD, Hurst DP, Barnett-Norris J, Lynch D, Reggio PH, Abood ME. McAllister SD, et al. J Biol Chem. 2004 Nov 12;279(46):48024-37. doi: 10.1074/jbc.M406648200. Epub 2004 Aug 23. J Biol Chem. 2004. PMID: 15326174 Free article.

6

Lipids, lipid rafts and caveolae: their importance for GPCR signaling and their centrality to the endocannabinoid system.

Barnett-Norris J, Lynch D, Reggio PH. Barnett-Norris J, et al. Life Sci. 2005 Aug 19;77(14):1625-39. doi: 10.1016/j.lfs.2005.05.040. Life Sci. 2005. PMID: 15993425 Review.

7

Biarylpyrazole inverse agonists at the cannabinoid CB1 receptor: importance of the C-3 carboxamide oxygen/lysine3.28(192) interaction.

Hurst D, Umejiego U, Lynch D, Seltzman H, Hyatt S, Roche M, McAllister S, Fleischer D, Kapur A, Abood M, Shi S, Jones J, Lewis D, Reggio P. Hurst D, et al. J Med Chem. 2006 Oct 5;49(20):5969-87. doi: 10.1021/jm060446b. J Med Chem. 2006. PMID: 17004712

8

Molecular dynamics simulations of the endocannabinoid N-arachidonoylethanolamine (anandamide) in a phospholipid bilayer: probing structure and dynamics.

Lynch DL, Reggio PH. Lynch DL, et al. J Med Chem. 2005 Jul 28;48(15):4824-33. doi: 10.1021/jm058185d. J Med Chem. 2005. PMID: 16033262

9

A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.

Hurst DP, Grossfield A, Lynch DL, Feller S, Romo TD, Gawrisch K, Pitman MC, Reggio PH. Hurst DP, et al. Among authors: lynch dl. J Biol Chem. 2010 Jun 4;285(23):17954-64. doi: 10.1074/jbc.M109.041590. Epub 2010 Mar 10. J Biol Chem. 2010. PMID: 20220143 Free PMC article.

10

Lipid bilayer molecular dynamics study of lipid-derived agonists of the putative cannabinoid receptor, GPR55.

Kotsikorou E, Lynch DL, Abood ME, Reggio PH. Kotsikorou E, et al. Among authors: lynch dl. Chem Phys Lipids. 2011 Feb;164(2):131-43. doi: 10.1016/j.chemphyslip.2010.12.003. Epub 2010 Dec 24. Chem Phys Lipids. 2011. PMID: 21185816 Free PMC article.

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