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Safety, tolerability, pharmacokinetics, and time course of pharmacologic response of the active metabolite of roxifiban, XV459, a glycoprotein IIb/IIIa antagonist, following oral administration in healthy volunteers.
Pieniaszek HJ Jr, Sy SK, Ebling W, Fossler MJ, Cain VA, Mondick JT, Ma S, Kornhauser DM. Pieniaszek HJ Jr, et al. J Clin Pharmacol. 2002 Jul;42(7):738-53. doi: 10.1177/009127002401102687. J Clin Pharmacol. 2002. PMID: 12092741 Clinical Trial.
Prospective testing for drug-dependent antibodies reduces the incidence of thrombocytopenia observed with the small molecule glycoprotein IIb/IIIa antagonist roxifiban: implications for the etiology of thrombocytopenia.
Seiffert D, Stern AM, Ebling W, Rossi RJ, Barrett YC, Wynn R, Hollis GF, He B, Kieras CJ, Pedicord DL, Cromley DA, Hua TA, Stein RB, Daly RN, Sferruzza A, Pieniaszek HJ, Billheimer JT. Seiffert D, et al. Blood. 2003 Jan 1;101(1):58-63. doi: 10.1182/blood-2002-02-0471. Epub 2002 Jun 28. Blood. 2003. PMID: 12393571 Free article. Clinical Trial.
44 results