Kendall RL - Search Results

1

Optimization of a pyrazolo[1,5-a]pyrimidine class of KDR kinase inhibitors: improvements in physical properties enhance cellular activity and pharmacokinetics.

Fraley ME, Rubino RS, Hoffman WF, Hambaugh SR, Arrington KL, Hungate RW, Bilodeau MT, Tebben AJ, Rutledge RZ, Kendall RL, McFall RC, Huckle WR, Coll KE, Thomas KA. Fraley ME, et al. Among authors: kendall rl. Bioorg Med Chem Lett. 2002 Dec 16;12(24):3537-41. doi: 10.1016/s0960-894x(02)00827-2. Bioorg Med Chem Lett. 2002. PMID: 12443771

2

Synthesis and initial SAR studies of 3,6-disubstituted pyrazolo[1,5-a]pyrimidines: a new class of KDR kinase inhibitors.

Fraley ME, Hoffman WF, Rubino RS, Hungate RW, Tebben AJ, Rutledge RZ, McFall RC, Huckle WR, Kendall RL, Coll KE, Thomas KA. Fraley ME, et al. Among authors: kendall rl. Bioorg Med Chem Lett. 2002 Oct 7;12(19):2767-70. doi: 10.1016/s0960-894x(02)00525-5. Bioorg Med Chem Lett. 2002. PMID: 12217372

3

Design and synthesis of 1,5-diarylbenzimidazoles as inhibitors of the VEGF-receptor KDR.

Bilodeau MT, Cunningham AM, Koester TJ, Ciecko PA, Coll KE, Huckle WR, Hungate RW, Kendall RL, McFall RC, Mao X, Rutledge RZ, Thomas KA. Bilodeau MT, et al. Among authors: kendall rl. Bioorg Med Chem Lett. 2003 Aug 4;13(15):2485-8. doi: 10.1016/s0960-894x(03)00485-2. Bioorg Med Chem Lett. 2003. PMID: 12852948

4

Discovery and evaluation of 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as a novel class of KDR kinase inhibitors.

Fraley ME, Arrington KL, Hambaugh SR, Hoffman WF, Cunningham AM, Young MB, Hungate RW, Tebben AJ, Rutledge RZ, Kendall RL, Huckle WR, McFall RC, Coll KE, Thomas KA. Fraley ME, et al. Among authors: kendall rl. Bioorg Med Chem Lett. 2003 Sep 15;13(18):2973-6. doi: 10.1016/s0960-894x(03)00627-9. Bioorg Med Chem Lett. 2003. PMID: 12941314

5

The discovery of N-(1,3-thiazol-2-yl)pyridin-2-amines as potent inhibitors of KDR kinase.

Bilodeau MT, Rodman LD, McGaughey GB, Coll KE, Koester TJ, Hoffman WF, Hungate RW, Kendall RL, McFall RC, Rickert KW, Rutledge RZ, Thomas KA. Bilodeau MT, et al. Among authors: kendall rl. Bioorg Med Chem Lett. 2004 Jun 7;14(11):2941-5. doi: 10.1016/j.bmcl.2004.03.052. Bioorg Med Chem Lett. 2004. PMID: 15125964

6

Vascular endothelial growth factor receptor KDR tyrosine kinase activity is increased by autophosphorylation of two activation loop tyrosine residues.

Kendall RL, Rutledge RZ, Mao X, Tebben AJ, Hungate RW, Thomas KA. Kendall RL, et al. J Biol Chem. 1999 Mar 5;274(10):6453-60. doi: 10.1074/jbc.274.10.6453. J Biol Chem. 1999. PMID: 10037737 Free article.

7

Inhibition of vascular endothelial cell growth factor activity by an endogenously encoded soluble receptor.

Kendall RL, Thomas KA. Kendall RL, et al. Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10705-9. doi: 10.1073/pnas.90.22.10705. Proc Natl Acad Sci U S A. 1993. PMID: 8248162 Free PMC article.

8

Identification of a natural soluble form of the vascular endothelial growth factor receptor, FLT-1, and its heterodimerization with KDR.

Kendall RL, Wang G, Thomas KA. Kendall RL, et al. Biochem Biophys Res Commun. 1996 Sep 13;226(2):324-8. doi: 10.1006/bbrc.1996.1355. Biochem Biophys Res Commun. 1996. PMID: 8806634

9

Specificity of vascular endothelial cell growth factor receptor ligand binding domains.

Kendall RL, Wang G, DiSalvo J, Thomas KA. Kendall RL, et al. Biochem Biophys Res Commun. 1994 May 30;201(1):326-30. doi: 10.1006/bbrc.1994.1705. Biochem Biophys Res Commun. 1994. PMID: 8198591

10

Design, synthesis, and evaluation of orally active benzimidazoles and benzoxazoles as vascular endothelial growth factor-2 receptor tyrosine kinase inhibitors.

Potashman MH, Bready J, Coxon A, DeMelfi TM Jr, DiPietro L, Doerr N, Elbaum D, Estrada J, Gallant P, Germain J, Gu Y, Harmange JC, Kaufman SA, Kendall R, Kim JL, Kumar GN, Long AM, Neervannan S, Patel VF, Polverino A, Rose P, Plas Sv, Whittington D, Zanon R, Zhao H. Potashman MH, et al. J Med Chem. 2007 Sep 6;50(18):4351-73. doi: 10.1021/jm070034i. Epub 2007 Aug 15. J Med Chem. 2007. PMID: 17696416

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