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A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.
Thomas J, Bramlett KS, Montrose C, Foxworthy P, Eacho PI, McCann D, Cao G, Kiefer A, McCowan J, Yu KL, Grese T, Chin WW, Burris TP, Michael LF. Thomas J, et al. Among authors: michael lf. J Biol Chem. 2003 Jan 24;278(4):2403-10. doi: 10.1074/jbc.M209629200. Epub 2002 Nov 18. J Biol Chem. 2003. PMID: 12441342 Free article.
A natural product ligand of the oxysterol receptor, liver X receptor.
Bramlett KS, Houck KA, Borchert KM, Dowless MS, Kulanthaivel P, Zhang Y, Beyer TP, Schmidt R, Thomas JS, Michael LF, Barr R, Montrose C, Eacho PI, Cao G, Burris TP. Bramlett KS, et al. Among authors: michael lf. J Pharmacol Exp Ther. 2003 Oct;307(1):291-6. doi: 10.1124/jpet.103.052852. Epub 2003 Jul 31. J Pharmacol Exp Ther. 2003. PMID: 12893846
T0901317 is a dual LXR/FXR agonist.
Houck KA, Borchert KM, Hepler CD, Thomas JS, Bramlett KS, Michael LF, Burris TP. Houck KA, et al. Among authors: michael lf. Mol Genet Metab. 2004 Sep-Oct;83(1-2):184-7. doi: 10.1016/j.ymgme.2004.07.007. Mol Genet Metab. 2004. PMID: 15464433
The pharmacology of LXR.
Michael LF, Schkeryantz JM, Burris TP. Michael LF, et al. Mini Rev Med Chem. 2005 Aug;5(8):729-40. doi: 10.2174/1389557054553767. Mini Rev Med Chem. 2005. PMID: 16101409 Review.
Molecular determinants of LXRalpha agonism.
Wang M, Thomas J, Burris TP, Schkeryantz J, Michael LF. Wang M, et al. Among authors: michael lf. J Mol Graph Model. 2003 Nov;22(2):173-81. doi: 10.1016/S1093-3263(03)00159-1. J Mol Graph Model. 2003. PMID: 12932788
Regulation of carbohydrate metabolism by the farnesoid X receptor.
Stayrook KR, Bramlett KS, Savkur RS, Ficorilli J, Cook T, Christe ME, Michael LF, Burris TP. Stayrook KR, et al. Among authors: michael lf. Endocrinology. 2005 Mar;146(3):984-91. doi: 10.1210/en.2004-0965. Epub 2004 Nov 24. Endocrinology. 2005. PMID: 15564327
40 results