Wallace AV - Search Results

1

Conformational changes in nitric oxide synthases induced by chlorzoxazone and nitroindazoles: crystallographic and computational analyses of inhibitor potency.

Rosenfeld RJ, Garcin ED, Panda K, Andersson G, Aberg A, Wallace AV, Morris GM, Olson AJ, Stuehr DJ, Tainer JA, Getzoff ED. Rosenfeld RJ, et al. Among authors: wallace av. Biochemistry. 2002 Nov 26;41(47):13915-25. doi: 10.1021/bi026313j. Biochemistry. 2002. PMID: 12437348

2

Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.

Garcin ED, Arvai AS, Rosenfeld RJ, Kroeger MD, Crane BR, Andersson G, Andrews G, Hamley PJ, Mallinder PR, Nicholls DJ, St-Gallay SA, Tinker AC, Gensmantel NP, Mete A, Cheshire DR, Connolly S, Stuehr DJ, Aberg A, Wallace AV, Tainer JA, Getzoff ED. Garcin ED, et al. Among authors: wallace av. Nat Chem Biol. 2008 Nov;4(11):700-7. doi: 10.1038/nchembio.115. Epub 2008 Oct 12. Nat Chem Biol. 2008. PMID: 18849972 Free PMC article.

3

2-aminopyridines as highly selective inducible nitric oxide synthase inhibitors. Differential binding modes dependent on nitrogen substitution.

Connolly S, Aberg A, Arvai A, Beaton HG, Cheshire DR, Cook AR, Cooper S, Cox D, Hamley P, Mallinder P, Millichip I, Nicholls DJ, Rosenfeld RJ, St-Gallay SA, Tainer J, Tinker AC, Wallace AV. Connolly S, et al. Among authors: wallace av. J Med Chem. 2004 Jun 3;47(12):3320-3. doi: 10.1021/jm031035n. J Med Chem. 2004. PMID: 15163211

4

The discovery of novel, potent and highly selective inhibitors of inducible nitric oxide synthase (iNOS).

Cheshire DR, Åberg A, Andersson GM, Andrews G, Beaton HG, Birkinshaw TN, Boughton-Smith N, Connolly S, Cook TR, Cooper A, Cooper SL, Cox D, Dixon J, Gensmantel N, Hamley PJ, Harrison R, Hartopp P, Käck H, Leeson PD, Luker T, Mete A, Millichip I, Nicholls DJ, Pimm AD, St-Gallay SA, Wallace AV. Cheshire DR, et al. Among authors: wallace av. Bioorg Med Chem Lett. 2011 Apr 15;21(8):2468-71. doi: 10.1016/j.bmcl.2011.02.061. Epub 2011 Feb 18. Bioorg Med Chem Lett. 2011. PMID: 21398123

5

Identification of iNOS inhibitors using InteraX.

Mallinder PR, Wallace AV, Allenby G. Mallinder PR, et al. Among authors: wallace av. J Biomol Screen. 2009 Mar;14(3):263-72. doi: 10.1177/1087057109331476. Epub 2009 Feb 11. J Biomol Screen. 2009. PMID: 19211775

6

1,2-Dihydro-4-quinazolinamines: potent, highly selective inhibitors of inducible nitric oxide synthase which show antiinflammatory activity in vivo.

Tinker AC, Beaton HG, Boughton-Smith N, Cook TR, Cooper SL, Fraser-Rae L, Hallam K, Hamley P, McInally T, Nicholls DJ, Pimm AD, Wallace AV. Tinker AC, et al. Among authors: wallace av. J Med Chem. 2003 Mar 13;46(6):913-6. doi: 10.1021/jm0255926. J Med Chem. 2003. PMID: 12620067

7

Selective inhibitors of inducible nitric oxide synthase: potential agents for the treatment of inflammatory diseases?

Tinker AC, Wallace AV. Tinker AC, et al. Among authors: wallace av. Curr Top Med Chem. 2006;6(2):77-92. doi: 10.2174/156802606775270297. Curr Top Med Chem. 2006. PMID: 16454760 Review.

8

3,4-Dihydro-1-isoquinolinamines: a novel class of nitric oxide synthase inhibitors with a range of isoform selectivity and potency.

Beaton H, Hamley P, Nicholls DJ, Tinker AC, Wallace AV. Beaton H, et al. Among authors: wallace av. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1023-6. doi: 10.1016/s0960-894x(01)00119-6. Bioorg Med Chem Lett. 2001. PMID: 11327580

9

Thienopyridines: nitric oxide synthase inhibitors with potent in vivo activity.

Beaton H, Boughton-Smith N, Hamley P, Ghelani A, Nicholls DJ, Tinker AC, Wallace AV. Beaton H, et al. Among authors: wallace av. Bioorg Med Chem Lett. 2001 Apr 23;11(8):1027-30. doi: 10.1016/s0960-894x(01)00120-2. Bioorg Med Chem Lett. 2001. PMID: 11327581

10

Reversibility of inhibition of human type II nitric oxide synthase.

Nicholls DJ, Kirk A, Wallace AV. Nicholls DJ, et al. Among authors: wallace av. Biochem Soc Trans. 1996 Feb;24(1):20S. doi: 10.1042/bst024020s. Biochem Soc Trans. 1996. PMID: 8674663 No abstract available.

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