Douthwaite S - Search Results

1

Resistance to the macrolide antibiotic tylosin is conferred by single methylations at 23S rRNA nucleotides G748 and A2058 acting in synergy.

Liu M, Douthwaite S. Liu M, et al. Among authors: douthwaite s. Proc Natl Acad Sci U S A. 2002 Nov 12;99(23):14658-63. doi: 10.1073/pnas.232580599. Epub 2002 Nov 4. Proc Natl Acad Sci U S A. 2002. PMID: 12417742 Free PMC article.

2

Interaction of the antibiotics clindamycin and lincomycin with Escherichia coli 23S ribosomal RNA.

Douthwaite S. Douthwaite S. Nucleic Acids Res. 1992 Sep 25;20(18):4717-20. doi: 10.1093/nar/20.18.4717. Nucleic Acids Res. 1992. PMID: 1383931 Free PMC article.

3

Functional interactions within 23S rRNA involving the peptidyltransferase center.

Douthwaite S. Douthwaite S. J Bacteriol. 1992 Feb;174(4):1333-8. doi: 10.1128/jb.174.4.1333-1338.1992. J Bacteriol. 1992. PMID: 1531223 Free PMC article.

4

Evidence for functional interaction between domains II and V of 23S ribosomal RNA from an erythromycin-resistant mutant.

Douthwaite S, Prince JB, Noller HF. Douthwaite S, et al. Proc Natl Acad Sci U S A. 1985 Dec;82(24):8330-4. doi: 10.1073/pnas.82.24.8330. Proc Natl Acad Sci U S A. 1985. PMID: 3909142 Free PMC article.

5

The conformation of 23S rRNA nucleotide A2058 determines its recognition by the ErmE methyltransferase.

Vester B, Hansen LH, Douthwaite S. Vester B, et al. Among authors: douthwaite s. RNA. 1995 Jul;1(5):501-9. RNA. 1995. PMID: 7489511 Free PMC article.

6

Domain V of 23S rRNA contains all the structural elements necessary for recognition by the ErmE methyltransferase.

Vester B, Douthwaite S. Vester B, et al. Among authors: douthwaite s. J Bacteriol. 1994 Nov;176(22):6999-7004. doi: 10.1128/jb.176.22.6999-7004.1994. J Bacteriol. 1994. PMID: 7961464 Free PMC article.

7

The antibiotics micrococcin and thiostrepton interact directly with 23S rRNA nucleotides 1067A and 1095A.

Rosendahl G, Douthwaite S. Rosendahl G, et al. Among authors: douthwaite s. Nucleic Acids Res. 1994 Feb 11;22(3):357-63. doi: 10.1093/nar/22.3.357. Nucleic Acids Res. 1994. PMID: 8127673 Free PMC article.

8

Requirement for a conserved, tertiary interaction in the core of 23S ribosomal RNA.

Aagaard C, Douthwaite S. Aagaard C, et al. Among authors: douthwaite s. Proc Natl Acad Sci U S A. 1994 Apr 12;91(8):2989-93. doi: 10.1073/pnas.91.8.2989. Proc Natl Acad Sci U S A. 1994. PMID: 8159692 Free PMC article.

9

Mutations in domain II of 23 S rRNA facilitate translation of a 23 S rRNA-encoded pentapeptide conferring erythromycin resistance.

Dam M, Douthwaite S, Tenson T, Mankin AS. Dam M, et al. Among authors: douthwaite s. J Mol Biol. 1996 May 31;259(1):1-6. doi: 10.1006/jmbi.1996.0296. J Mol Biol. 1996. PMID: 8648637

10

Core sequence in the RNA motif recognized by the ErmE methyltransferase revealed by relaxing the fidelity of the enzyme for its target.

Hansen LH, Vester B, Douthwaite S. Hansen LH, et al. Among authors: douthwaite s. RNA. 1999 Jan;5(1):93-101. doi: 10.1017/s1355838299981451. RNA. 1999. PMID: 9917069 Free PMC article.

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