Sacchettini JC - Search Results

1

Overexpression of inhA, but not kasA, confers resistance to isoniazid and ethionamide in Mycobacterium smegmatis, M. bovis BCG and M. tuberculosis.

Larsen MH, Vilchèze C, Kremer L, Besra GS, Parsons L, Salfinger M, Heifets L, Hazbon MH, Alland D, Sacchettini JC, Jacobs WR Jr. Larsen MH, et al. Among authors: sacchettini jc. Mol Microbiol. 2002 Oct;46(2):453-66. doi: 10.1046/j.1365-2958.2002.03162.x. Mol Microbiol. 2002. PMID: 12406221 Free article.

2

Enzymatic characterization of the target for isoniazid in Mycobacterium tuberculosis.

Quémard A, Sacchettini JC, Dessen A, Vilcheze C, Bittman R, Jacobs WR Jr, Blanchard JS. Quémard A, et al. Among authors: sacchettini jc. Biochemistry. 1995 Jul 4;34(26):8235-41. doi: 10.1021/bi00026a004. Biochemistry. 1995. PMID: 7599116

3

Crystal structure and function of the isoniazid target of Mycobacterium tuberculosis.

Dessen A, Quémard A, Blanchard JS, Jacobs WR Jr, Sacchettini JC. Dessen A, et al. Among authors: sacchettini jc. Science. 1995 Mar 17;267(5204):1638-41. doi: 10.1126/science.7886450. Science. 1995. PMID: 7886450

4

The structure and function of the isoniazid target in M. tuberculosis.

Sacchettini JC, Blanchard JS. Sacchettini JC, et al. Res Microbiol. 1996 Jan-Feb;147(1-2):36-43. doi: 10.1016/0923-2508(96)80201-4. Res Microbiol. 1996. PMID: 8761720 Free article. Review. No abstract available.

5

Modification of the NADH of the isoniazid target (InhA) from Mycobacterium tuberculosis.

Rozwarski DA, Grant GA, Barton DH, Jacobs WR Jr, Sacchettini JC. Rozwarski DA, et al. Among authors: sacchettini jc. Science. 1998 Jan 2;279(5347):98-102. doi: 10.1126/science.279.5347.98. Science. 1998. PMID: 9417034

6

The mabA gene from the inhA operon of Mycobacterium tuberculosis encodes a 3-ketoacyl reductase that fails to confer isoniazid resistance.

Banerjee A, Sugantino M, Sacchettini JC, Jacobs WR. Banerjee A, et al. Among authors: sacchettini jc. Microbiology (Reading). 1998 Oct;144 ( Pt 10):2697-2704. doi: 10.1099/00221287-144-10-2697. Microbiology (Reading). 1998. PMID: 9802011 Free article.

7

Mechanisms for isoniazid action and resistance.

Miesel L, Rozwarski DA, Sacchettini JC, Jacobs WR Jr. Miesel L, et al. Among authors: sacchettini jc. Novartis Found Symp. 1998;217:209-20; discussion 220-1. doi: 10.1002/0470846526.ch15. Novartis Found Symp. 1998. PMID: 9949810 Review.

8

Crystal structure of the Mycobacterium tuberculosis enoyl-ACP reductase, InhA, in complex with NAD+ and a C16 fatty acyl substrate.

Rozwarski DA, Vilchèze C, Sugantino M, Bittman R, Sacchettini JC. Rozwarski DA, et al. Among authors: sacchettini jc. J Biol Chem. 1999 May 28;274(22):15582-9. doi: 10.1074/jbc.274.22.15582. J Biol Chem. 1999. PMID: 10336454 Free article.

9

Crystal structure of the secreted form of antigen 85C reveals potential targets for mycobacterial drugs and vaccines.

Ronning DR, Klabunde T, Besra GS, Vissa VD, Belisle JT, Sacchettini JC. Ronning DR, et al. Among authors: sacchettini jc. Nat Struct Biol. 2000 Feb;7(2):141-6. doi: 10.1038/72413. Nat Struct Biol. 2000. PMID: 10655617

10

Inactivation of the inhA-encoded fatty acid synthase II (FASII) enoyl-acyl carrier protein reductase induces accumulation of the FASI end products and cell lysis of Mycobacterium smegmatis.

Vilchèze C, Morbidoni HR, Weisbrod TR, Iwamoto H, Kuo M, Sacchettini JC, Jacobs WR Jr. Vilchèze C, et al. Among authors: sacchettini jc. J Bacteriol. 2000 Jul;182(14):4059-67. doi: 10.1128/JB.182.14.4059-4067.2000. J Bacteriol. 2000. PMID: 10869086 Free PMC article.

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