Cleary ML - Search Results

1

Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties.

Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M. Yokoyama A, et al. Among authors: cleary ml. Blood. 2002 Nov 15;100(10):3710-8. doi: 10.1182/blood-2002-04-1015. Epub 2002 Jun 28. Blood. 2002. PMID: 12393701 Free article.

2

Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.

Yokoyama A, Ficara F, Murphy MJ, Meisel C, Naresh A, Kitabayashi I, Cleary ML. Yokoyama A, et al. Among authors: cleary ml. J Cell Sci. 2011 Jul 1;124(Pt 13):2208-19. doi: 10.1242/jcs.080523. J Cell Sci. 2011. PMID: 21670200 Free PMC article.

3

The AF10 leucine zipper is required for leukemic transformation of myeloid progenitors by MLL-AF10.

DiMartino JF, Ayton PM, Chen EH, Naftzger CC, Young BD, Cleary ML. DiMartino JF, et al. Among authors: cleary ml. Blood. 2002 May 15;99(10):3780-5. doi: 10.1182/blood.v99.10.3780. Blood. 2002. PMID: 11986236 Free article.

4

A carboxy-terminal domain of ELL is required and sufficient for immortalization of myeloid progenitors by MLL-ELL.

DiMartino JF, Miller T, Ayton PM, Landewe T, Hess JL, Cleary ML, Shilatifard A. DiMartino JF, et al. Among authors: cleary ml. Blood. 2000 Dec 1;96(12):3887-93. Blood. 2000. PMID: 11090074 Free article.

5

Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression.

Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML. Yokoyama A, et al. Among authors: cleary ml. Mol Cell Biol. 2004 Jul;24(13):5639-49. doi: 10.1128/MCB.24.13.5639-5649.2004. Mol Cell Biol. 2004. PMID: 15199122 Free PMC article.

6

Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein.

Ayton PM, Chen EH, Cleary ML. Ayton PM, et al. Among authors: cleary ml. Mol Cell Biol. 2004 Dec;24(23):10470-8. doi: 10.1128/MCB.24.23.10470-10478.2004. Mol Cell Biol. 2004. PMID: 15542854 Free PMC article.

7

Menin critically links MLL proteins with LEDGF on cancer-associated target genes.

Yokoyama A, Cleary ML. Yokoyama A, et al. Among authors: cleary ml. Cancer Cell. 2008 Jul 8;14(1):36-46. doi: 10.1016/j.ccr.2008.05.003. Cancer Cell. 2008. PMID: 18598942 Free PMC article.

8

A higher-order complex containing AF4 and ENL family proteins with P-TEFb facilitates oncogenic and physiologic MLL-dependent transcription.

Yokoyama A, Lin M, Naresh A, Kitabayashi I, Cleary ML. Yokoyama A, et al. Among authors: cleary ml. Cancer Cell. 2010 Feb 17;17(2):198-212. doi: 10.1016/j.ccr.2009.12.040. Cancer Cell. 2010. PMID: 20153263 Free PMC article.

9

Self-association mediated by the Ras association 1 domain of AF6 activates the oncogenic potential of MLL-AF6.

Liedtke M, Ayton PM, Somervaille TC, Smith KS, Cleary ML. Liedtke M, et al. Among authors: cleary ml. Blood. 2010 Jul 8;116(1):63-70. doi: 10.1182/blood-2009-09-243386. Epub 2010 Apr 15. Blood. 2010. PMID: 20395419 Free PMC article.

10

MLL becomes functional through intra-molecular interaction not by proteolytic processing.

Yokoyama A, Ficara F, Murphy MJ, Meisel C, Hatanaka C, Kitabayashi I, Cleary ML. Yokoyama A, et al. Among authors: cleary ml. PLoS One. 2013 Sep 10;8(9):e73649. doi: 10.1371/journal.pone.0073649. eCollection 2013. PLoS One. 2013. PMID: 24040009 Free PMC article.

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