Lashuel HA - Search Results

1

Alpha-synuclein, especially the Parkinson's disease-associated mutants, forms pore-like annular and tubular protofibrils.

Lashuel HA, Petre BM, Wall J, Simon M, Nowak RJ, Walz T, Lansbury PT Jr. Lashuel HA, et al. J Mol Biol. 2002 Oct 4;322(5):1089-102. doi: 10.1016/s0022-2836(02)00735-0. J Mol Biol. 2002. PMID: 12367530

2

Neurodegenerative disease: amyloid pores from pathogenic mutations.

Lashuel HA, Hartley D, Petre BM, Walz T, Lansbury PT Jr. Lashuel HA, et al. Nature. 2002 Jul 18;418(6895):291. doi: 10.1038/418291a. Nature. 2002. PMID: 12124613

3

The UCH-L1 gene encodes two opposing enzymatic activities that affect alpha-synuclein degradation and Parkinson's disease susceptibility.

Liu Y, Fallon L, Lashuel HA, Liu Z, Lansbury PT Jr. Liu Y, et al. Among authors: lashuel ha. Cell. 2002 Oct 18;111(2):209-18. doi: 10.1016/s0092-8674(02)01012-7. Cell. 2002. PMID: 12408865 Free article.

4

Murine apolipoprotein serum amyloid A in solution forms a hexamer containing a central channel.

Wang L, Lashuel HA, Walz T, Colon W. Wang L, et al. Among authors: lashuel ha. Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):15947-52. doi: 10.1073/pnas.252508399. Epub 2002 Nov 27. Proc Natl Acad Sci U S A. 2002. PMID: 12456883 Free PMC article.

5

Dissociation of amyloid fibrils of alpha-synuclein and transthyretin by pressure reveals their reversible nature and the formation of water-excluded cavities.

Foguel D, Suarez MC, Ferrão-Gonzales AD, Porto TC, Palmieri L, Einsiedler CM, Andrade LR, Lashuel HA, Lansbury PT, Kelly JW, Silva JL. Foguel D, et al. Among authors: lashuel ha. Proc Natl Acad Sci U S A. 2003 Aug 19;100(17):9831-6. doi: 10.1073/pnas.1734009100. Epub 2003 Aug 4. Proc Natl Acad Sci U S A. 2003. PMID: 12900507 Free PMC article.

6

Mixtures of wild-type and a pathogenic (E22G) form of Abeta40 in vitro accumulate protofibrils, including amyloid pores.

Lashuel HA, Hartley DM, Petre BM, Wall JS, Simon MN, Walz T, Lansbury PT Jr. Lashuel HA, et al. J Mol Biol. 2003 Sep 26;332(4):795-808. doi: 10.1016/s0022-2836(03)00927-6. J Mol Biol. 2003. PMID: 12972252

7

Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line.

Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT Jr. Liu Y, et al. Among authors: lashuel ha. Chem Biol. 2003 Sep;10(9):837-46. doi: 10.1016/j.chembiol.2003.08.010. Chem Biol. 2003. PMID: 14522054

8

Abeta protofibrils possess a stable core structure resistant to hydrogen exchange.

Kheterpal I, Lashuel HA, Hartley DM, Walz T, Lansbury PT Jr, Wetzel R. Kheterpal I, et al. Among authors: lashuel ha. Biochemistry. 2003 Dec 9;42(48):14092-8. doi: 10.1021/bi0357816. Biochemistry. 2003. PMID: 14640676

9

Interactions among alpha-synuclein, dopamine, and biomembranes: some clues for understanding neurodegeneration in Parkinson's disease.

Rochet JC, Outeiro TF, Conway KA, Ding TT, Volles MJ, Lashuel HA, Bieganski RM, Lindquist SL, Lansbury PT. Rochet JC, et al. Among authors: lashuel ha. J Mol Neurosci. 2004;23(1-2):23-34. doi: 10.1385/jmn:23:1-2:023. J Mol Neurosci. 2004. PMID: 15126689 Review.

10

Quaternary structure, protein dynamics, and synaptic function of SAP97 controlled by L27 domain interactions.

Nakagawa T, Futai K, Lashuel HA, Lo I, Okamoto K, Walz T, Hayashi Y, Sheng M. Nakagawa T, et al. Among authors: lashuel ha. Neuron. 2004 Oct 28;44(3):453-67. doi: 10.1016/j.neuron.2004.10.012. Neuron. 2004. PMID: 15504326 Free article.

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