Marcinkeviciene J - Search Results

1

Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.

Haque TS, Tadesse S, Marcinkeviciene J, Rogers MJ, Sizemore C, Kopcho LM, Amsler K, Ecret LD, Zhan DL, Hobbs F, Slee A, Trainor GL, Stern AM, Copeland RA, Combs AP. Haque TS, et al. Among authors: marcinkeviciene j. J Med Chem. 2002 Oct 10;45(21):4669-78. doi: 10.1021/jm020112w. J Med Chem. 2002. PMID: 12361393

2

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, Lentz KA, Grace JE, Burton CR, Toyn JH, Barten DM, Marcinkeviciene J, Meredith JE, Albright CF, Macor JE. Thompson LA, et al. Among authors: marcinkeviciene j. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6909-15. doi: 10.1016/j.bmcl.2011.06.116. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21974952

3

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis.

Copeland RA, Marcinkeviciene J, Haque TS, Kopcho LM, Jiang W, Wang K, Ecret LD, Sizemore C, Amsler KA, Foster L, Tadesse S, Combs AP, Stern AM, Trainor GL, Slee A, Rogers MJ, Hobbs F. Copeland RA, et al. Among authors: marcinkeviciene j. J Biol Chem. 2000 Oct 27;275(43):33373-8. doi: 10.1074/jbc.M004451200. J Biol Chem. 2000. PMID: 10938275 Free article.

4

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.

Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, Burton CR, Barten DM, Toyn JH, Meredith JE, Albright CF, Bronson JJ, Macor JE, Thompson LA. Marcin LR, et al. Among authors: marcinkeviciene ja. Bioorg Med Chem Lett. 2011 Jan 1;21(1):537-41. doi: 10.1016/j.bmcl.2010.10.079. Bioorg Med Chem Lett. 2011. PMID: 21078556

5

Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.

Marcinkeviciene J, Kopcho LM, Yang T, Copeland RA, Glass BM, Combs AP, Falahatpisheh N, Thompson L. Marcinkeviciene J, et al. J Biol Chem. 2002 Aug 9;277(32):28677-82. doi: 10.1074/jbc.M203120200. Epub 2002 May 23. J Biol Chem. 2002. PMID: 12029090 Free article.

6

Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.

Marcinkeviciene J, Tinney LM, Wang KH, Rogers MJ, Copeland RA. Marcinkeviciene J, et al. Biochemistry. 1999 Oct 5;38(40):13129-37. doi: 10.1021/bi990674q. Biochemistry. 1999. PMID: 10529184

7

A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism.

Marcinkeviciene J, Jiang W, Locke G, Kopcho LM, Rogers MJ, Copeland RA. Marcinkeviciene J, et al. Arch Biochem Biophys. 2000 May 1;377(1):178-86. doi: 10.1006/abbi.2000.1769. Arch Biochem Biophys. 2000. PMID: 10775458

8

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones.

Marcinkeviciene J, Rogers MJ, Kopcho L, Jiang W, Wang K, Murphy DJ, Lippy J, Link S, Chung TD, Hobbs F, Haque T, Trainor GL, Slee A, Stern AM, Copeland RA. Marcinkeviciene J, et al. Biochem Pharmacol. 2000 Aug 1;60(3):339-42. doi: 10.1016/s0006-2952(00)00348-8. Biochem Pharmacol. 2000. PMID: 10856428

9

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide.

Marcinkeviciene J, Luo Y, Graciani NR, Combs AP, Copeland RA. Marcinkeviciene J, et al. J Biol Chem. 2001 Jun 29;276(26):23790-4. doi: 10.1074/jbc.M101896200. Epub 2001 Apr 16. J Biol Chem. 2001. PMID: 11306583 Free article.

10

Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.

Toulokhonova L, Metzler WJ, Witmer MR, Copeland RA, Marcinkeviciene J. Toulokhonova L, et al. Among authors: marcinkeviciene j. J Biol Chem. 2003 Feb 14;278(7):4582-9. doi: 10.1074/jbc.M210471200. Epub 2002 Nov 27. J Biol Chem. 2003. PMID: 12458195 Free article.

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