Kopcho LM - Search Results

1

Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.

Haque TS, Tadesse S, Marcinkeviciene J, Rogers MJ, Sizemore C, Kopcho LM, Amsler K, Ecret LD, Zhan DL, Hobbs F, Slee A, Trainor GL, Stern AM, Copeland RA, Combs AP. Haque TS, et al. Among authors: kopcho lm. J Med Chem. 2002 Oct 10;45(21):4669-78. doi: 10.1021/jm020112w. J Med Chem. 2002. PMID: 12361393

2

A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism.

Marcinkeviciene J, Jiang W, Locke G, Kopcho LM, Rogers MJ, Copeland RA. Marcinkeviciene J, et al. Among authors: kopcho lm. Arch Biochem Biophys. 2000 May 1;377(1):178-86. doi: 10.1006/abbi.2000.1769. Arch Biochem Biophys. 2000. PMID: 10775458

3

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones.

Marcinkeviciene J, Rogers MJ, Kopcho L, Jiang W, Wang K, Murphy DJ, Lippy J, Link S, Chung TD, Hobbs F, Haque T, Trainor GL, Slee A, Stern AM, Copeland RA. Marcinkeviciene J, et al. Biochem Pharmacol. 2000 Aug 1;60(3):339-42. doi: 10.1016/s0006-2952(00)00348-8. Biochem Pharmacol. 2000. PMID: 10856428

4

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis.

Copeland RA, Marcinkeviciene J, Haque TS, Kopcho LM, Jiang W, Wang K, Ecret LD, Sizemore C, Amsler KA, Foster L, Tadesse S, Combs AP, Stern AM, Trainor GL, Slee A, Rogers MJ, Hobbs F. Copeland RA, et al. Among authors: kopcho lm. J Biol Chem. 2000 Oct 27;275(43):33373-8. doi: 10.1074/jbc.M004451200. J Biol Chem. 2000. PMID: 10938275 Free article.

5

Enoyl-ACP reductase (FabI) of Haemophilus influenzae: steady-state kinetic mechanism and inhibition by triclosan and hexachlorophene.

Marcinkeviciene J, Jiang W, Kopcho LM, Locke G, Luo Y, Copeland RA. Marcinkeviciene J, et al. Among authors: kopcho lm. Arch Biochem Biophys. 2001 Jun 1;390(1):101-8. doi: 10.1006/abbi.2001.2349. Arch Biochem Biophys. 2001. PMID: 11368521

6

Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.

Marcinkeviciene J, Kopcho LM, Yang T, Copeland RA, Glass BM, Combs AP, Falahatpisheh N, Thompson L. Marcinkeviciene J, et al. Among authors: kopcho lm. J Biol Chem. 2002 Aug 9;277(32):28677-82. doi: 10.1074/jbc.M203120200. Epub 2002 May 23. J Biol Chem. 2002. PMID: 12029090 Free article.

7

Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.

Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, Ramamurthy V, Morin PE, Camac DM, King RW, Lasut AL, Ross OH, Hillman MC, Fish B, Shen K, Dowling RL, Kim YB, Graciani NR, Collins D, Combs AP, George H, Thompson LA, Copeland RA. Kopcho LM, et al. Arch Biochem Biophys. 2003 Feb 15;410(2):307-16. doi: 10.1016/s0003-9861(02)00690-2. Arch Biochem Biophys. 2003. PMID: 12573291

8

Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach.

Kopcho LM, Kim YB, Wang A, Liu MA, Kirby MS, Marcinkeviciene J. Kopcho LM, et al. Arch Biochem Biophys. 2005 Apr 15;436(2):367-76. doi: 10.1016/j.abb.2005.02.015. Arch Biochem Biophys. 2005. PMID: 15797249

9

Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).

Kim YB, Kopcho LM, Kirby MS, Hamann LG, Weigelt CA, Metzler WJ, Marcinkeviciene J. Kim YB, et al. Among authors: kopcho lm. Arch Biochem Biophys. 2006 Jan 1;445(1):9-18. doi: 10.1016/j.abb.2005.11.010. Epub 2005 Dec 5. Arch Biochem Biophys. 2006. PMID: 16364232

10

P-glycoprotein efflux and other factors limit brain amyloid beta reduction by beta-site amyloid precursor protein-cleaving enzyme 1 inhibitors in mice.

Meredith JE Jr, Thompson LA, Toyn JH, Marcin L, Barten DM, Marcinkeviciene J, Kopcho L, Kim Y, Lin A, Guss V, Burton C, Iben L, Polson C, Cantone J, Ford M, Drexler D, Fiedler T, Lentz KA, Grace JE Jr, Kolb J, Corsa J, Pierdomenico M, Jones K, Olson RE, Macor JE, Albright CF. Meredith JE Jr, et al. J Pharmacol Exp Ther. 2008 Aug;326(2):502-13. doi: 10.1124/jpet.108.138974. Epub 2008 May 22. J Pharmacol Exp Ther. 2008. PMID: 18499745

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