Copeland RA - Search Results

1

Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.

Haque TS, Tadesse S, Marcinkeviciene J, Rogers MJ, Sizemore C, Kopcho LM, Amsler K, Ecret LD, Zhan DL, Hobbs F, Slee A, Trainor GL, Stern AM, Copeland RA, Combs AP. Haque TS, et al. Among authors: copeland ra. J Med Chem. 2002 Oct 10;45(21):4669-78. doi: 10.1021/jm020112w. J Med Chem. 2002. PMID: 12361393

2

Beyond U0126. Dianion chemistry leading to the rapid synthesis of a series of potent MEK inhibitors.

Wityak J, Hobbs FW, Gardner DS, Santella JB 3rd, Petraitis JJ, Sun JH, Favata MF, Daulerio AJ, Horiuchi KY, Copeland RA, Scherle PA, Jaffe BD, Trzaskos JM, Magolda RL, Trainor GL, Duncia JV. Wityak J, et al. Among authors: copeland ra. Bioorg Med Chem Lett. 2004 Mar 22;14(6):1483-6. doi: 10.1016/j.bmcl.2004.01.012. Bioorg Med Chem Lett. 2004. PMID: 15006386

3

Synthesis and in vivo evaluation of cyclic diaminopropane BACE-1 inhibitors.

Thompson LA, Shi J, Decicco CP, Tebben AJ, Olson RE, Boy KM, Guernon JM, Good AC, Liauw A, Zheng C, Copeland RA, Combs AP, Trainor GL, Camac DM, Muckelbauer JK, Lentz KA, Grace JE, Burton CR, Toyn JH, Barten DM, Marcinkeviciene J, Meredith JE, Albright CF, Macor JE. Thompson LA, et al. Among authors: copeland ra. Bioorg Med Chem Lett. 2011 Nov 15;21(22):6909-15. doi: 10.1016/j.bmcl.2011.06.116. Epub 2011 Jul 2. Bioorg Med Chem Lett. 2011. PMID: 21974952

4

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis.

Copeland RA, Marcinkeviciene J, Haque TS, Kopcho LM, Jiang W, Wang K, Ecret LD, Sizemore C, Amsler KA, Foster L, Tadesse S, Combs AP, Stern AM, Trainor GL, Slee A, Rogers MJ, Hobbs F. Copeland RA, et al. J Biol Chem. 2000 Oct 27;275(43):33373-8. doi: 10.1074/jbc.M004451200. J Biol Chem. 2000. PMID: 10938275 Free article.

5

Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.

Marcinkeviciene J, Kopcho LM, Yang T, Copeland RA, Glass BM, Combs AP, Falahatpisheh N, Thompson L. Marcinkeviciene J, et al. Among authors: copeland ra. J Biol Chem. 2002 Aug 9;277(32):28677-82. doi: 10.1074/jbc.M203120200. Epub 2002 May 23. J Biol Chem. 2002. PMID: 12029090 Free article.

6

Dihydroorotate dehydrogenase B of Enterococcus faecalis. Characterization and insights into chemical mechanism.

Marcinkeviciene J, Tinney LM, Wang KH, Rogers MJ, Copeland RA. Marcinkeviciene J, et al. Among authors: copeland ra. Biochemistry. 1999 Oct 5;38(40):13129-37. doi: 10.1021/bi990674q. Biochemistry. 1999. PMID: 10529184

7

A second dihydroorotate dehydrogenase (Type A) of the human pathogen Enterococcus faecalis: expression, purification, and steady-state kinetic mechanism.

Marcinkeviciene J, Jiang W, Locke G, Kopcho LM, Rogers MJ, Copeland RA. Marcinkeviciene J, et al. Among authors: copeland ra. Arch Biochem Biophys. 2000 May 1;377(1):178-86. doi: 10.1006/abbi.2000.1769. Arch Biochem Biophys. 2000. PMID: 10775458

8

Selective inhibition of bacterial dihydroorotate dehydrogenases by thiadiazolidinediones.

Marcinkeviciene J, Rogers MJ, Kopcho L, Jiang W, Wang K, Murphy DJ, Lippy J, Link S, Chung TD, Hobbs F, Haque T, Trainor GL, Slee A, Stern AM, Copeland RA. Marcinkeviciene J, et al. Among authors: copeland ra. Biochem Pharmacol. 2000 Aug 1;60(3):339-42. doi: 10.1016/s0006-2952(00)00348-8. Biochem Pharmacol. 2000. PMID: 10856428

9

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide.

Marcinkeviciene J, Luo Y, Graciani NR, Combs AP, Copeland RA. Marcinkeviciene J, et al. Among authors: copeland ra. J Biol Chem. 2001 Jun 29;276(26):23790-4. doi: 10.1074/jbc.M101896200. Epub 2001 Apr 16. J Biol Chem. 2001. PMID: 11306583 Free article.

10

Glutamyl-gamma-boronate inhibitors of bacterial Glu-tRNA(Gln) amidotransferase.

Decicco CP, Nelson DJ, Luo Y, Shen L, Horiuchi KY, Amsler KM, Foster LA, Spitz SM, Merrill JJ, Sizemore CF, Rogers KC, Copeland RA, Harpel MR. Decicco CP, et al. Among authors: copeland ra. Bioorg Med Chem Lett. 2001 Sep 17;11(18):2561-4. doi: 10.1016/s0960-894x(01)00499-1. Bioorg Med Chem Lett. 2001. PMID: 11549469

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