Prestwich GD - Search Results

1

Concise synthesis of acyl migration-blocked 1,1-difluorinated analogues of lysophosphatidic acid.

Xu Y, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. J Org Chem. 2002 Oct 4;67(20):7158-61. doi: 10.1021/jo0203037. J Org Chem. 2002. PMID: 12354017

2

New metabolically stabilized analogues of lysophosphatidic acid: agonists, antagonists and enzyme inhibitors.

Prestwich GD, Xu Y, Qian L, Gajewiak J, Jiang G. Prestwich GD, et al. Biochem Soc Trans. 2005 Dec;33(Pt 6):1357-61. doi: 10.1042/BST0331357. Biochem Soc Trans. 2005. PMID: 16246118 Review.

3

Synthesis of chiral (alpha,alpha-difluoroalkyl)phosphonate analogues of (lyso)phosphatidic acid via hydrolytic kinetic resolution.

Xu Y, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. Org Lett. 2002 Nov 14;4(23):4021-4. doi: 10.1021/ol026684s. Org Lett. 2002. PMID: 12423076

4

Identification of an intracellular receptor for lysophosphatidic acid (LPA): LPA is a transcellular PPARgamma agonist.

McIntyre TM, Pontsler AV, Silva AR, St Hilaire A, Xu Y, Hinshaw JC, Zimmerman GA, Hama K, Aoki J, Arai H, Prestwich GD. McIntyre TM, et al. Among authors: prestwich gd. Proc Natl Acad Sci U S A. 2003 Jan 7;100(1):131-6. doi: 10.1073/pnas.0135855100. Epub 2002 Dec 26. Proc Natl Acad Sci U S A. 2003. PMID: 12502787 Free PMC article.

5

Synthesis of alpha-fluorinated phosphonates from alpha-fluorovinylphosphonates: a new route to analogues of lysophosphatidic acid.

Xu Y, Qian L, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. Org Lett. 2003 Jun 26;5(13):2267-70. doi: 10.1021/ol034597+. Org Lett. 2003. PMID: 12816425

6

Synthesis of monofluorinated analogues of lysophosphatidic acid.

Xu Y, Qian L, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. J Org Chem. 2003 Jun 27;68(13):5320-30. doi: 10.1021/jo020729l. J Org Chem. 2003. PMID: 12816494

7

Synthesis of migration-resistant hydroxyethoxy analogues of lysophosphatidic acid.

Qian L, Xu Y, Arai H, Aoki J, McIntyre TM, Prestwich GD. Qian L, et al. Among authors: prestwich gd. Org Lett. 2003 Nov 27;5(24):4685-8. doi: 10.1021/ol0358758. Org Lett. 2003. PMID: 14627415

8

Enantioselective responses to a phosphorothioate analogue of lysophosphatidic acid with LPA3 receptor-selective agonist activity.

Qian L, Xu Y, Hasegawa Y, Aoki J, Mills GB, Prestwich GD. Qian L, et al. Among authors: prestwich gd. J Med Chem. 2003 Dec 18;46(26):5575-8. doi: 10.1021/jm034207p. J Med Chem. 2003. PMID: 14667211

9

Alkyl lysophosphatidic acid and fluoromethylene phosphonate analogs as metabolically-stabilized agonists for LPA receptors.

Xu Y, Tanaka M, Arai H, Aoki J, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. Bioorg Med Chem Lett. 2004 Nov 1;14(21):5323-8. doi: 10.1016/j.bmcl.2004.08.019. Bioorg Med Chem Lett. 2004. PMID: 15454220

10

Structure-activity relationships of fluorinated lysophosphatidic acid analogues.

Xu Y, Aoki J, Shimizu K, Umezu-Goto M, Hama K, Takanezawa Y, Yu S, Mills GB, Arai H, Qian L, Prestwich GD. Xu Y, et al. Among authors: prestwich gd. J Med Chem. 2005 May 5;48(9):3319-27. doi: 10.1021/jm049186t. J Med Chem. 2005. PMID: 15857137

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