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A phase I trial of antibody directed enzyme prodrug therapy (ADEPT) in patients with advanced colorectal carcinoma or other CEA producing tumours.
Francis RJ, Sharma SK, Springer C, Green AJ, Hope-Stone LD, Sena L, Martin J, Adamson KL, Robbins A, Gumbrell L, O'Malley D, Tsiompanou E, Shahbakhti H, Webley S, Hochhauser D, Hilson AJ, Blakey D, Begent RH. Francis RJ, et al. Among authors: sharma sk. Br J Cancer. 2002 Sep 9;87(6):600-7. doi: 10.1038/sj.bjc.6600517. Br J Cancer. 2002. PMID: 12237768 Free PMC article. Clinical Trial.
Antibody-directed enzyme prodrug therapy (ADEPT) for cancer.
Bagshawe KD, Sharma SK, Begent RH. Bagshawe KD, et al. Among authors: sharma sk. Expert Opin Biol Ther. 2004 Nov;4(11):1777-89. doi: 10.1517/14712598.4.11.1777. Expert Opin Biol Ther. 2004. PMID: 15500406 Review.
A phase I study of single administration of antibody-directed enzyme prodrug therapy with the recombinant anti-carcinoembryonic antigen antibody-enzyme fusion protein MFECP1 and a bis-iodo phenol mustard prodrug.
Mayer A, Francis RJ, Sharma SK, Tolner B, Springer CJ, Martin J, Boxer GM, Bell J, Green AJ, Hartley JA, Cruickshank C, Wren J, Chester KA, Begent RH. Mayer A, et al. Among authors: sharma sk. Clin Cancer Res. 2006 Nov 1;12(21):6509-16. doi: 10.1158/1078-0432.CCR-06-0769. Clin Cancer Res. 2006. PMID: 17085666 Clinical Trial.
Radiolabelling of glycosylated MFE-23::CPG2 fusion protein (MFECP1) with 99mTc for quantitation of tumour antibody-enzyme localisation in antibody-directed enzyme pro-drug therapy (ADEPT).
Francis RJ, Mather SJ, Chester K, Sharma SK, Bhatia J, Pedley RB, Waibel R, Green AJ, Begent RH. Francis RJ, et al. Among authors: sharma sk. Eur J Nucl Med Mol Imaging. 2004 Aug;31(8):1090-6. doi: 10.1007/s00259-004-1474-4. Epub 2004 Mar 17. Eur J Nucl Med Mol Imaging. 2004. PMID: 15029458
3,393 results