Harder KW - Search Results

1

Constitutive activation of the SRC family kinase Hck results in spontaneous pulmonary inflammation and an enhanced innate immune response.

Ernst M, Inglese M, Scholz GM, Harder KW, Clay FJ, Bozinovski S, Waring P, Darwiche R, Kay T, Sly P, Collins R, Turner D, Hibbs ML, Anderson GP, Dunn AR. Ernst M, et al. Among authors: harder kw. J Exp Med. 2002 Sep 2;196(5):589-604. doi: 10.1084/jem.20020873. J Exp Med. 2002. PMID: 12208875 Free PMC article.

2

Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage.

Harder KW, Parsons LM, Armes J, Evans N, Kountouri N, Clark R, Quilici C, Grail D, Hodgson GS, Dunn AR, Hibbs ML. Harder KW, et al. Immunity. 2001 Oct;15(4):603-15. doi: 10.1016/s1074-7613(01)00208-4. Immunity. 2001. PMID: 11672542 Free article.

3

The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent.

Xu Y, Beavitt SJ, Harder KW, Hibbs ML, Tarlinton DM. Xu Y, et al. Among authors: harder kw. J Immunol. 2002 Dec 15;169(12):6910-8. doi: 10.4049/jimmunol.169.12.6910. J Immunol. 2002. PMID: 12471124

4

Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity.

Hibbs ML, Harder KW, Armes J, Kountouri N, Quilici C, Casagranda F, Dunn AR, Tarlinton DM. Hibbs ML, et al. Among authors: harder kw. J Exp Med. 2002 Dec 16;196(12):1593-604. doi: 10.1084/jem.20020515. J Exp Med. 2002. PMID: 12486102 Free PMC article.

5

Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase.

Odom S, Gomez G, Kovarova M, Furumoto Y, Ryan JJ, Wright HV, Gonzalez-Espinosa C, Hibbs ML, Harder KW, Rivera J. Odom S, et al. Among authors: harder kw. J Exp Med. 2004 Jun 7;199(11):1491-502. doi: 10.1084/jem.20040382. Epub 2004 Jun 1. J Exp Med. 2004. PMID: 15173205 Free PMC article.

6

Perturbed myelo/erythropoiesis in Lyn-deficient mice is similar to that in mice lacking the inhibitory phosphatases SHP-1 and SHIP-1.

Harder KW, Quilici C, Naik E, Inglese M, Kountouri N, Turner A, Zlatic K, Tarlinton DM, Hibbs ML. Harder KW, et al. Blood. 2004 Dec 15;104(13):3901-10. doi: 10.1182/blood-2003-12-4396. Epub 2004 Aug 31. Blood. 2004. PMID: 15339845 Free article.

7

Lyn tyrosine kinase: accentuating the positive and the negative.

Xu Y, Harder KW, Huntington ND, Hibbs ML, Tarlinton DM. Xu Y, et al. Among authors: harder kw. Immunity. 2005 Jan;22(1):9-18. doi: 10.1016/j.immuni.2004.12.004. Immunity. 2005. PMID: 15664155 Free article. Review.

8

Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity.

Beavitt SJ, Harder KW, Kemp JM, Jones J, Quilici C, Casagranda F, Lam E, Turner D, Brennan S, Sly PD, Tarlinton DM, Anderson GP, Hibbs ML. Beavitt SJ, et al. Among authors: harder kw. J Immunol. 2005 Aug 1;175(3):1867-75. doi: 10.4049/jimmunol.175.3.1867. J Immunol. 2005. PMID: 16034130

9

The duplicitous nature of the Lyn tyrosine kinase in growth factor signaling.

Hibbs ML, Harder KW. Hibbs ML, et al. Among authors: harder kw. Growth Factors. 2006 Jun;24(2):137-49. doi: 10.1080/08977190600581327. Growth Factors. 2006. PMID: 16801133

10

Csk-binding protein mediates sequential enzymatic down-regulation and degradation of Lyn in erythropoietin-stimulated cells.

Ingley E, Schneider JR, Payne CJ, McCarthy DJ, Harder KW, Hibbs ML, Klinken SP. Ingley E, et al. Among authors: harder kw. J Biol Chem. 2006 Oct 20;281(42):31920-9. doi: 10.1074/jbc.M602637200. Epub 2006 Aug 18. J Biol Chem. 2006. PMID: 16920712 Free article.

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