Brognard J - Search Results

1

Variable apoptotic response of NSCLC cells to inhibition of the MEK/ERK pathway by small molecules or dominant negative mutants.

Brognard J, Dennis PA. Brognard J, et al. Cell Death Differ. 2002 Sep;9(9):893-904. doi: 10.1038/sj.cdd.4401054. Cell Death Differ. 2002. PMID: 12181740

2

Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.

Brognard J, Clark AS, Ni Y, Dennis PA. Brognard J, et al. Cancer Res. 2001 May 15;61(10):3986-97. Cancer Res. 2001. PMID: 11358816

3

Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.

West KA, Brognard J, Clark AS, Linnoila IR, Yang X, Swain SM, Harris C, Belinsky S, Dennis PA. West KA, et al. Among authors: brognard j. J Clin Invest. 2003 Jan;111(1):81-90. doi: 10.1172/JCI16147. J Clin Invest. 2003. PMID: 12511591 Free PMC article.

4

Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.

Kozikowski AP, Sun H, Brognard J, Dennis PA. Kozikowski AP, et al. Among authors: brognard j. J Am Chem Soc. 2003 Feb 5;125(5):1144-5. doi: 10.1021/ja0285159. J Am Chem Soc. 2003. PMID: 12553797

5

Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.

Castillo SS, Brognard J, Petukhov PA, Zhang C, Tsurutani J, Granville CA, Li M, Jung M, West KA, Gills JG, Kozikowski AP, Dennis PA. Castillo SS, et al. Among authors: brognard j. Cancer Res. 2004 Apr 15;64(8):2782-92. doi: 10.1158/0008-5472.can-03-1530. Cancer Res. 2004. PMID: 15087394

6

Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.

West KA, Linnoila IR, Brognard J, Belinsky S, Harris C, Dennis PA. West KA, et al. Among authors: brognard j. Chest. 2004 May;125(5 Suppl):101S-2S. doi: 10.1378/chest.125.5_suppl.101s. Chest. 2004. PMID: 15136436 No abstract available.

7

Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.

Tsurutani J, Castillo SS, Brognard J, Granville CA, Zhang C, Gills JJ, Sayyah J, Dennis PA. Tsurutani J, et al. Among authors: brognard j. Carcinogenesis. 2005 Jul;26(7):1182-95. doi: 10.1093/carcin/bgi072. Epub 2005 Mar 24. Carcinogenesis. 2005. PMID: 15790591

8

Paradox-breaking RAF inhibitors that also target SRC are effective in drug-resistant BRAF mutant melanoma.

Girotti MR, Lopes F, Preece N, Niculescu-Duvaz D, Zambon A, Davies L, Whittaker S, Saturno G, Viros A, Pedersen M, Suijkerbuijk BM, Menard D, McLeary R, Johnson L, Fish L, Ejiama S, Sanchez-Laorden B, Hohloch J, Carragher N, Macleod K, Ashton G, Marusiak AA, Fusi A, Brognard J, Frame M, Lorigan P, Marais R, Springer C. Girotti MR, et al. Among authors: brognard j. Cancer Cell. 2015 Jan 12;27(1):85-96. doi: 10.1016/j.ccell.2014.11.006. Epub 2014 Dec 11. Cancer Cell. 2015. PMID: 25500121 Free PMC article.

9

Somatically mutated ABL1 is an actionable and essential NSCLC survival gene.

Testoni E, Stephenson NL, Torres-Ayuso P, Marusiak AA, Trotter EW, Hudson A, Hodgkinson CL, Morrow CJ, Dive C, Brognard J. Testoni E, et al. Among authors: brognard j. EMBO Mol Med. 2016 Feb 1;8(2):105-16. doi: 10.15252/emmm.201505456. EMBO Mol Med. 2016. PMID: 26758680 Free PMC article.

10

Mixed lineage kinases activate MEK independently of RAF to mediate resistance to RAF inhibitors.

Marusiak AA, Edwards ZC, Hugo W, Trotter EW, Girotti MR, Stephenson NL, Kong X, Gartside MG, Fawdar S, Hudson A, Breitwieser W, Hayward NK, Marais R, Lo RS, Brognard J. Marusiak AA, et al. Among authors: brognard j. Nat Commun. 2014 May 22;5:3901. doi: 10.1038/ncomms4901. Nat Commun. 2014. PMID: 24849047 Free PMC article.

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