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Elastase mediates the release of growth factors from lung in vivo.
Buczek-Thomas JA, Lucey EC, Stone PJ, Chu CL, Rich CB, Carreras I, Goldstein RH, Foster JA, Nugent MA. Buczek-Thomas JA, et al. Among authors: stone pj. Am J Respir Cell Mol Biol. 2004 Sep;31(3):344-50. doi: 10.1165/rcmb.2003-0420OC. Epub 2004 Jun 10. Am J Respir Cell Mol Biol. 2004. PMID: 15191913
Neutrophil elastase-initiated EGFR/MEK/ERK signaling counteracts stabilizing effect of autocrine TGF-beta on tropoelastin mRNA in lung fibroblasts.
DiCamillo SJ, Yang S, Panchenko MV, Toselli PA, Naggar EF, Rich CB, Stone PJ, Nugent MA, Panchenko MP. DiCamillo SJ, et al. Among authors: stone pj. Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L232-43. doi: 10.1152/ajplung.00530.2005. Epub 2006 Feb 10. Am J Physiol Lung Cell Mol Physiol. 2006. PMID: 16473861 Free article.
Besides its direct elastolytic activity, NE releases soluble epidermal growth factor receptor (EGFR) ligands and initiates EGFR/MEK/ERK signaling to downregulate tropoelastin mRNA in neonatal rat lung fibroblasts (DiCamillo SJ, Carreras I, Panchenko MV, Stone PJ, Nu …
Besides its direct elastolytic activity, NE releases soluble epidermal growth factor receptor (EGFR) ligands and initiates EGFR/MEK/ERK sign …
A zipper network model of the failure mechanics of extracellular matrices.
Ritter MC, Jesudason R, Majumdar A, Stamenovic D, Buczek-Thomas JA, Stone PJ, Nugent MA, Suki B. Ritter MC, et al. Among authors: stone pj. Proc Natl Acad Sci U S A. 2009 Jan 27;106(4):1081-6. doi: 10.1073/pnas.0808414106. Epub 2009 Jan 14. Proc Natl Acad Sci U S A. 2009. PMID: 19144920 Free PMC article.
136 results