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Sophoranone, extracted from a traditional Chinese medicine Shan Dou Gen, induces apoptosis in human leukemia U937 cells via formation of reactive oxygen species and opening of mitochondrial permeability transition pores.
Kajimoto S, Takanashi N, Kajimoto T, Xu M, Cao J, Masuda Y, Aiuchi T, Nakajo S, Ida Y, Nakaya K. Kajimoto S, et al. Among authors: masuda y. Int J Cancer. 2002 Jun 20;99(6):879-90. doi: 10.1002/ijc.10414. Int J Cancer. 2002. PMID: 12115492
A tyrosine kinase inhibitor, beta-hydroxyisovalerylshikonin, induced apoptosis in human lung cancer DMS114 cells through reduction of dUTP nucleotidohydrolase activity.
Kajimoto S, Horie M, Manabe H, Masuda Y, Shibayama-Imazu T, Nakajo S, Gong XF, Obama T, Itabe H, Nakaya K. Kajimoto S, et al. Among authors: masuda y. Biochim Biophys Acta. 2008 Jan;1782(1):41-50. doi: 10.1016/j.bbadis.2007.11.004. Epub 2007 Nov 22. Biochim Biophys Acta. 2008. PMID: 18078828 Free article.
2,601 results