Mackman RL - Search Results

1

2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

Mackman RL, Hui HC, Breitenbucher JG, Katz BA, Luong C, Martelli A, McGee D, Radika K, Sendzik M, Spencer JR, Sprengeler PA, Tario J, Verner E, Wang J. Mackman RL, et al. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2019-22. doi: 10.1016/s0960-894x(02)00311-6. Bioorg Med Chem Lett. 2002. PMID: 12113832

2

Structural basis for selectivity of a small molecule, S1-binding, submicromolar inhibitor of urokinase-type plasminogen activator.

Katz BA, Mackman R, Luong C, Radika K, Martelli A, Sprengeler PA, Wang J, Chan H, Wong L. Katz BA, et al. Chem Biol. 2000 Apr;7(4):299-312. doi: 10.1016/s1074-5521(00)00104-6. Chem Biol. 2000. PMID: 10779411

3

A novel serine protease inhibition motif involving a multi-centered short hydrogen bonding network at the active site.

Katz BA, Elrod K, Luong C, Rice MJ, Mackman RL, Sprengeler PA, Spencer J, Hataye J, Janc J, Link J, Litvak J, Rai R, Rice K, Sideris S, Verner E, Young W. Katz BA, et al. Among authors: mackman rl. J Mol Biol. 2001 Apr 13;307(5):1451-86. doi: 10.1006/jmbi.2001.4516. J Mol Biol. 2001. PMID: 11292354

4

Development of serine protease inhibitors displaying a multicentered short (<2.3 A) hydrogen bond binding mode: inhibitors of urokinase-type plasminogen activator and factor Xa.

Verner E, Katz BA, Spencer JR, Allen D, Hataye J, Hruzewicz W, Hui HC, Kolesnikov A, Li Y, Luong C, Martelli A, Radika K, Rai R, She M, Shrader W, Sprengeler PA, Trapp S, Wang J, Young WB, Mackman RL. Verner E, et al. Among authors: mackman rl. J Med Chem. 2001 Aug 16;44(17):2753-71. doi: 10.1021/jm0100638. J Med Chem. 2001. PMID: 11495587

5

Exploiting subsite S1 of trypsin-like serine proteases for selectivity: potent and selective inhibitors of urokinase-type plasminogen activator.

Mackman RL, Katz BA, Breitenbucher JG, Hui HC, Verner E, Luong C, Liu L, Sprengeler PA. Mackman RL, et al. J Med Chem. 2001 Nov 8;44(23):3856-71. doi: 10.1021/jm010244+. J Med Chem. 2001. PMID: 11689072

6

Engineering inhibitors highly selective for the S1 sites of Ser190 trypsin-like serine protease drug targets.

Katz BA, Sprengeler PA, Luong C, Verner E, Elrod K, Kirtley M, Janc J, Spencer JR, Breitenbucher JG, Hui H, McGee D, Allen D, Martelli A, Mackman RL. Katz BA, et al. Among authors: mackman rl. Chem Biol. 2001 Nov;8(11):1107-21. doi: 10.1016/s1074-5521(01)00084-9. Chem Biol. 2001. PMID: 11731301

7

4-Aminoarylguanidine and 4-aminobenzamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.

Spencer JR, McGee D, Allen D, Katz BA, Luong C, Sendzik M, Squires N, Mackman RL. Spencer JR, et al. Among authors: mackman rl. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2023-6. doi: 10.1016/s0960-894x(02)00312-8. Bioorg Med Chem Lett. 2002. PMID: 12113833

8

Contribution of multicentered short hydrogen bond arrays to potency of active site-directed serine protease inhibitors.

Katz BA, Spencer JR, Elrod K, Luong C, Mackman RL, Rice M, Sprengeler PA, Allen D, Janc J. Katz BA, et al. Among authors: mackman rl. J Am Chem Soc. 2002 Oct 2;124(39):11657-68. doi: 10.1021/ja020082m. J Am Chem Soc. 2002. PMID: 12296731

9

Elaborate manifold of short hydrogen bond arrays mediating binding of active site-directed serine protease inhibitors.

Katz BA, Elrod K, Verner E, Mackman RL, Luong C, Shrader WD, Sendzik M, Spencer JR, Sprengeler PA, Kolesnikov A, Tai VW, Hui HC, Breitenbucher JG, Allen D, Janc JW. Katz BA, et al. Among authors: mackman rl. J Mol Biol. 2003 May 23;329(1):93-120. doi: 10.1016/s0022-2836(03)00399-1. J Mol Biol. 2003. PMID: 12742021

10

Design and synthesis of beta-amino-alpha-hydroxy amide derivatives as inhibitors of MetAP2 and HUVEC growth.

Sendzik M, Janc JW, Cabuslay R, Honigberg L, Mackman RL, Magill C, Squires N, Waldeck N. Sendzik M, et al. Among authors: mackman rl. Bioorg Med Chem Lett. 2004 Jun 21;14(12):3181-4. doi: 10.1016/j.bmcl.2004.04.004. Bioorg Med Chem Lett. 2004. PMID: 15149671

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