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2-(2-Hydroxy-3-alkoxyphenyl)-1H-benzimidazole-5-carboxamidine derivatives as potent and selective urokinase-type plasminogen activator inhibitors.
Mackman RL, Hui HC, Breitenbucher JG, Katz BA, Luong C, Martelli A, McGee D, Radika K, Sendzik M, Spencer JR, Sprengeler PA, Tario J, Verner E, Wang J. Mackman RL, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2002 Aug 5;12(15):2019-22. doi: 10.1016/s0960-894x(02)00311-6. Bioorg Med Chem Lett. 2002. PMID: 12113832
Novel non-benzimidazole chk2 kinase inhibitors.
McClure KJ, Huang L, Arienti KL, Axe FU, Brunmark A, Blevitt J, Breitenbucher JG. McClure KJ, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2006 Apr 1;16(7):1924-8. doi: 10.1016/j.bmcl.2005.12.096. Epub 2006 Jan 25. Bioorg Med Chem Lett. 2006. PMID: 16442290
Novel human histamine H(3) receptor antagonists.
Shah C, McAtee L, Breitenbucher JG, Rudolph D, Li X, Lovenberg TW, Mazur C, Wilson SJ, Carruthers NI. Shah C, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2002 Nov 18;12(22):3309-12. doi: 10.1016/s0960-894x(02)00738-2. Bioorg Med Chem Lett. 2002. PMID: 12392739
Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands.
Lee-Dutra A, Arienti KL, Buzard DJ, Hack MD, Khatuya H, Desai PJ, Nguyen S, Thurmond RL, Karlsson L, Edwards JP, Breitenbucher JG. Lee-Dutra A, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2006 Dec 1;16(23):6043-8. doi: 10.1016/j.bmcl.2006.08.117. Epub 2006 Sep 20. Bioorg Med Chem Lett. 2006. PMID: 16990005
SAR studies of 1,5-diarylpyrazole-based CCK1 receptor antagonists.
Gomez L, Hack MD, McClure K, Sehon C, Huang L, Morton M, Li L, Barrett TD, Shankley N, Breitenbucher JG. Gomez L, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2007 Dec 1;17(23):6493-8. doi: 10.1016/j.bmcl.2007.09.093. Epub 2007 Oct 1. Bioorg Med Chem Lett. 2007. PMID: 17933530
Novel ketooxazole based inhibitors of fatty acid amide hydrolase (FAAH).
Timmons A, Seierstad M, Apodaca R, Epperson M, Pippel D, Brown S, Chang L, Scott B, Webb M, Chaplan SR, Breitenbucher JG. Timmons A, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2008 Mar 15;18(6):2109-13. doi: 10.1016/j.bmcl.2008.01.091. Epub 2008 Jan 30. Bioorg Med Chem Lett. 2008. PMID: 18289847
Discovery of a novel series of selective HCN1 blockers.
McClure KJ, Maher M, Wu N, Chaplan SR, Eckert WA 3rd, Lee DH, Wickenden AD, Hermann M, Allison B, Hawryluk N, Breitenbucher JG, Grice CA. McClure KJ, et al. Among authors: breitenbucher jg. Bioorg Med Chem Lett. 2011 Sep 15;21(18):5197-201. doi: 10.1016/j.bmcl.2011.07.051. Epub 2011 Jul 23. Bioorg Med Chem Lett. 2011. PMID: 21824780
46 results