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Changes in human immunodeficiency virus type 1 Gag at positions L449 and P453 are linked to I50V protease mutants in vivo and cause reduction of sensitivity to amprenavir and improved viral fitness in vitro.
Maguire MF, Guinea R, Griffin P, Macmanus S, Elston RC, Wolfram J, Richards N, Hanlon MH, Porter DJ, Wrin T, Parkin N, Tisdale M, Furfine E, Petropoulos C, Snowden BW, Kleim JP. Maguire MF, et al. Among authors: tisdale m. J Virol. 2002 Aug;76(15):7398-406. doi: 10.1128/jvi.76.15.7398-7406.2002. J Virol. 2002. PMID: 12097552 Free PMC article.
Emergence of resistance to protease inhibitor amprenavir in human immunodeficiency virus type 1-infected patients: selection of four alternative viral protease genotypes and influence of viral susceptibility to coadministered reverse transcriptase nucleoside inhibitors.
Maguire M, Shortino D, Klein A, Harris W, Manohitharajah V, Tisdale M, Elston R, Yeo J, Randall S, Xu F, Parker H, May J, Snowden W. Maguire M, et al. Among authors: tisdale m. Antimicrob Agents Chemother. 2002 Mar;46(3):731-8. doi: 10.1128/AAC.46.3.731-738.2002. Antimicrob Agents Chemother. 2002. PMID: 11850255 Free PMC article. Clinical Trial.
HIV-1 reverse transcriptase and protease resistance mutations selected during 16-72 weeks of therapy in isolates from antiretroviral therapy-experienced patients receiving abacavir/efavirenz/amprenavir in the CNA2007 study.
Ait-Khaled M, Rakik A, Griffin P, Stone C, Richards N, Thomas D, Falloon J, Tisdale M; CNA2007 International Study Team. Ait-Khaled M, et al. Among authors: tisdale m. Antivir Ther. 2003 Apr;8(2):111-20. Antivir Ther. 2003. PMID: 12741623 Clinical Trial.
A novel genotype encoding a single amino acid insertion and five other substitutions between residues 64 and 74 of the HIV-1 reverse transcriptase confers high-level cross-resistance to nucleoside reverse transcriptase inhibitors. Abacavir CNA2007 International Study Group.
Rakik A, Ait-Khaled M, Griffin P, Thomas TA, Tisdale M, Kleim JP. Rakik A, et al. Among authors: tisdale m. J Acquir Immune Defic Syndr. 1999 Oct 1;22(2):139-45. doi: 10.1097/00126334-199910010-00005. J Acquir Immune Defic Syndr. 1999. PMID: 10843527
335 results