Mortishire-Smith RJ - Search Results

1

Metabolic profiling of rodent biological fluids via 1H NMR spectroscopy using a 1 mm microlitre probe.

Griffin JL, Nicholls AW, Keun HC, Mortishire-Smith RJ, Nicholson JK, Kuehn T. Griffin JL, et al. Analyst. 2002 May;127(5):582-4. doi: 10.1039/b201207c. Analyst. 2002. PMID: 12081031

2

NMR spectroscopic-based metabonomic studies of urinary metabolite variation in acclimatizing germ-free rats.

Nicholls AW, Mortishire-Smith RJ, Nicholson JK. Nicholls AW, et al. Chem Res Toxicol. 2003 Nov;16(11):1395-404. doi: 10.1021/tx0340293. Chem Res Toxicol. 2003. PMID: 14615964

3

Use of metabonomics to identify impaired fatty acid metabolism as the mechanism of a drug-induced toxicity.

Mortishire-Smith RJ, Skiles GL, Lawrence JW, Spence S, Nicholls AW, Johnson BA, Nicholson JK. Mortishire-Smith RJ, et al. Chem Res Toxicol. 2004 Feb;17(2):165-73. doi: 10.1021/tx034123j. Chem Res Toxicol. 2004. PMID: 14967004

4

Metabolomic investigation of CLN6 neuronal ceroid lipofuscinosis in affected South Hampshire sheep.

Pears MR, Salek RM, Palmer DN, Kay GW, Mortishire-Smith RJ, Griffin JL. Pears MR, et al. J Neurosci Res. 2007 Nov 15;85(15):3494-504. doi: 10.1002/jnr.21343. J Neurosci Res. 2007. PMID: 17510975

5

A functional analysis of mouse models of cardiac disease through metabolic profiling.

Jones GL, Sang E, Goddard C, Mortishire-Smith RJ, Sweatman BC, Haselden JN, Davies K, Grace AA, Clarke K, Griffin JL. Jones GL, et al. J Biol Chem. 2005 Mar 4;280(9):7530-9. doi: 10.1074/jbc.M410200200. Epub 2004 Nov 16. J Biol Chem. 2005. PMID: 15546876 Free article.

6

High resolution 1H NMR-based metabolomics indicates a neurotransmitter cycling deficit in cerebral tissue from a mouse model of Batten disease.

Pears MR, Cooper JD, Mitchison HM, Mortishire-Smith RJ, Pearce DA, Griffin JL. Pears MR, et al. J Biol Chem. 2005 Dec 30;280(52):42508-14. doi: 10.1074/jbc.M507380200. Epub 2005 Oct 20. J Biol Chem. 2005. PMID: 16239221 Free article.

7

Deletion of btn1, an orthologue of CLN3, increases glycolysis and perturbs amino acid metabolism in the fission yeast model of Batten disease.

Pears MR, Codlin S, Haines RL, White IJ, Mortishire-Smith RJ, Mole SE, Griffin JL. Pears MR, et al. Among authors: mortishire smith rj. Mol Biosyst. 2010 Jun;6(6):1093-102. doi: 10.1039/b915670d. Epub 2010 Mar 17. Mol Biosyst. 2010. PMID: 20485751

8

A metabolomic comparison of mouse models of the Neuronal Ceroid Lipofuscinoses.

Salek RM, Pears MR, Cooper JD, Mitchison HM, Pearce DA, Mortishire-Smith RJ, Griffin JL. Salek RM, et al. Among authors: mortishire smith rj. J Biomol NMR. 2011 Apr;49(3-4):175-84. doi: 10.1007/s10858-011-9491-7. Epub 2011 Apr 3. J Biomol NMR. 2011. PMID: 21461951 Free PMC article.

9

Metabolite identification in drug discovery.

Watt AP, Mortishire-Smith RJ, Gerhard U, Thomas SR. Watt AP, et al. Curr Opin Drug Discov Devel. 2003 Jan;6(1):57-65. Curr Opin Drug Discov Devel. 2003. PMID: 12613277 Review.

10

1H NMR study of the conformation and absolute stereochemistry of two spirocyclic NK-1 antagonists.

Herbert RH, Gerhard U, Mortishire-Smith RJ, Thomas SR, Hollingworth G. Herbert RH, et al. Magn Reson Chem. 2005 Aug;43(8):658-61. doi: 10.1002/mrc.1604. Magn Reson Chem. 2005. PMID: 15924294

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