Hawkins RE - Search Results

1

Primary polyclonal human T lymphocytes targeted to carcino-embryonic antigens and neural cell adhesion molecule tumor antigens by CD3zeta-based chimeric immune receptors.

Gilham DE, O'Neil A, Hughes C, Guest RD, Kirillova N, Lehane M, Hawkins RE. Gilham DE, et al. Among authors: hawkins re. J Immunother. 2002 Mar-Apr;25(2):139-51. doi: 10.1097/00002371-200203000-00002. J Immunother. 2002. PMID: 12074044

2

Engineering T-cells with antibody-based chimeric receptors for effective cancer therapy.

Thistlethwaite F, Mansoor W, Gilham DE, Hawkins RE. Thistlethwaite F, et al. Among authors: hawkins re. Curr Opin Mol Ther. 2005 Feb;7(1):48-55. Curr Opin Mol Ther. 2005. PMID: 15732529 Review.

3

The role of extracellular spacer regions in the optimal design of chimeric immune receptors: evaluation of four different scFvs and antigens.

Guest RD, Hawkins RE, Kirillova N, Cheadle EJ, Arnold J, O'Neill A, Irlam J, Chester KA, Kemshead JT, Shaw DM, Embleton MJ, Stern PL, Gilham DE. Guest RD, et al. Among authors: hawkins re. J Immunother. 2005 May-Jun;28(3):203-11. doi: 10.1097/01.cji.0000161397.96582.59. J Immunother. 2005. PMID: 15838376

4

Eradication of established B-cell lymphoma by CD19-specific murine T cells is dependent on host lymphopenic environment and can be mediated by CD4+ and CD8+ T cells.

Cheadle EJ, Hawkins RE, Batha H, Rothwell DG, Ashton G, Gilham DE. Cheadle EJ, et al. Among authors: hawkins re. J Immunother. 2009 Apr;32(3):207-18. doi: 10.1097/CJI.0b013e318194a921. J Immunother. 2009. PMID: 19242379

5

Building better chimeric antigen receptors for adoptive T cell therapy.

Bridgeman JS, Hawkins RE, Hombach AA, Abken H, Gilham DE. Bridgeman JS, et al. Among authors: hawkins re. Curr Gene Ther. 2010 Apr;10(2):77-90. doi: 10.2174/156652310791111001. Curr Gene Ther. 2010. PMID: 20222863 Review.

6

The optimal antigen response of chimeric antigen receptors harboring the CD3zeta transmembrane domain is dependent upon incorporation of the receptor into the endogenous TCR/CD3 complex.

Bridgeman JS, Hawkins RE, Bagley S, Blaylock M, Holland M, Gilham DE. Bridgeman JS, et al. Among authors: hawkins re. J Immunol. 2010 Jun 15;184(12):6938-49. doi: 10.4049/jimmunol.0901766. Epub 2010 May 17. J Immunol. 2010. PMID: 20483753

7

Definition and application of good manufacturing process-compliant production of CEA-specific chimeric antigen receptor expressing T-cells for phase I/II clinical trial.

Guest RD, Kirillova N, Mowbray S, Gornall H, Rothwell DG, Cheadle EJ, Austin E, Smith K, Watt SM, Kühlcke K, Westwood N, Thistlethwaite F, Hawkins RE, Gilham DE. Guest RD, et al. Among authors: hawkins re. Cancer Immunol Immunother. 2014 Feb;63(2):133-45. doi: 10.1007/s00262-013-1492-9. Epub 2013 Nov 5. Cancer Immunol Immunother. 2014. PMID: 24190544 Free PMC article. Clinical Trial.

8

Gene therapy of patient-derived T lymphocytes to target and eradicate colorectal hepatic metastases.

Sheen AJ, Irlam J, Kirillova N, Guest RD, Sherlock DJ, Hawkins RE, Gilham DE. Sheen AJ, et al. Among authors: hawkins re. Dis Colon Rectum. 2003 Jun;46(6):793-804. doi: 10.1007/s10350-004-6659-1. Dis Colon Rectum. 2003. PMID: 12794582

9

Killing of non-Hodgkin lymphoma cells by autologous CD19 engineered T cells.

Cheadle EJ, Gilham DE, Thistlethwaite FC, Radford JA, Hawkins RE. Cheadle EJ, et al. Among authors: hawkins re. Br J Haematol. 2005 May;129(3):322-32. doi: 10.1111/j.1365-2141.2005.05456.x. Br J Haematol. 2005. PMID: 15842655 Free article.

10

Combination of vaccination and chimeric receptor expressing T cells provides improved active therapy of tumors.

Jiang HR, Gilham DE, Mulryan K, Kirillova N, Hawkins RE, Stern PL. Jiang HR, et al. Among authors: hawkins re. J Immunol. 2006 Oct 1;177(7):4288-98. doi: 10.4049/jimmunol.177.7.4288. J Immunol. 2006. PMID: 16982863

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