Gruber A - Search Results

1

The thrombin mutant W215A/E217A shows safe and potent anticoagulant and antithrombotic effects in vivo.

Gruber A, Cantwell AM, Di Cera E, Hanson SR. Gruber A, et al. J Biol Chem. 2002 Aug 2;277(31):27581-4. doi: 10.1074/jbc.C200237200. Epub 2002 Jun 17. J Biol Chem. 2002. PMID: 12070133 Free article.

2

Antithrombotic effects of combining activated protein C and urokinase in nonhuman primates.

Gruber A, Harker LA, Hanson SR, Kelly AB, Griffin JH. Gruber A, et al. Circulation. 1991 Dec;84(6):2454-62. doi: 10.1161/01.cir.84.6.2454. Circulation. 1991. PMID: 1835678

3

In vivo and in vitro complexes of activated protein C with two inhibitors in baboons.

España F, Gruber A, Heeb MJ, Hanson SR, Harker LA, Griffin JH. España F, et al. Among authors: gruber a. Blood. 1991 Apr 15;77(8):1754-60. Blood. 1991. PMID: 1849759 Free article.

4

Inhibition of thrombus formation by activated recombinant protein C in a primate model of arterial thrombosis.

Gruber A, Hanson SR, Kelly AB, Yan BS, Bang N, Griffin JH, Harker LA. Gruber A, et al. Circulation. 1990 Aug;82(2):578-85. doi: 10.1161/01.cir.82.2.578. Circulation. 1990. PMID: 2372904

5

Inhibition of platelet-dependent thrombus formation by human activated protein C in a primate model.

Gruber A, Griffin JH, Harker LA, Hanson SR. Gruber A, et al. Blood. 1989 Feb 15;73(3):639-42. Blood. 1989. PMID: 2917194 Free article.

6

Antithrombotic effects of thrombin-induced activation of endogenous protein C in primates.

Hanson SR, Griffin JH, Harker LA, Kelly AB, Esmon CT, Gruber A. Hanson SR, et al. Among authors: gruber a. J Clin Invest. 1993 Oct;92(4):2003-12. doi: 10.1172/JCI116795. J Clin Invest. 1993. PMID: 8408654 Free PMC article.

7

Factor XI-dependence of surface- and tissue factor-initiated thrombus propagation in primates.

Gruber A, Hanson SR. Gruber A, et al. Blood. 2003 Aug 1;102(3):953-5. doi: 10.1182/blood-2003-01-0324. Epub 2003 Apr 10. Blood. 2003. PMID: 12689935 Free article.

8

Potential new targets for antithrombotic therapy.

Gruber A, Hanson SR. Gruber A, et al. Curr Pharm Des. 2003;9(28):2367-74. doi: 10.2174/1381612033453938. Curr Pharm Des. 2003. PMID: 14529397 Review.

9

Soluble thrombomodulin is antithrombotic in the presence of neutralising antibodies to protein C and reduces circulating activated protein C levels in primates.

Tanaka KA, Fernández JA, Marzec UM, Kelly AB, Mohri M, Griffin JH, Hanson SR, Gruber A. Tanaka KA, et al. Among authors: gruber a. Br J Haematol. 2006 Jan;132(2):197-203. doi: 10.1111/j.1365-2141.2005.05855.x. Br J Haematol. 2006. PMID: 16398653 Free article.

10

Limited generation of activated protein C during infusion of the protein C activator thrombin analog W215A/E217A in primates.

Gruber A, Fernández JA, Bush L, Marzec U, Griffin JH, Hanson SR, DI Cera E. Gruber A, et al. J Thromb Haemost. 2006 Feb;4(2):392-7. doi: 10.1111/j.1538-7836.2006.01760.x. J Thromb Haemost. 2006. PMID: 16420571 Free article.

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