López-Rodríguez ML - Search Results

1

Design, synthesis and pharmacological evaluation of 5-hydroxytryptamine(1a) receptor ligands to explore the three-dimensional structure of the receptor.

López-Rodríguez ML, Vicente B, Deupi X, Barrondo S, Olivella M, Morcillo MJ, Behamú B, Ballesteros JA, Sallés J, Pardo L. López-Rodríguez ML, et al. Mol Pharmacol. 2002 Jul;62(1):15-21. doi: 10.1124/mol.62.1.15. Mol Pharmacol. 2002. PMID: 12065750

2

Optimization of the pharmacophore model for 5-HT7R antagonism. Design and synthesis of new naphtholactam and naphthosultam derivatives.

López-Rodríguez ML, Porras E, Morcillo MJ, Benhamú B, Soto LJ, Lavandera JL, Ramos JA, Olivella M, Campillo M, Pardo L. López-Rodríguez ML, et al. J Med Chem. 2003 Dec 18;46(26):5638-50. doi: 10.1021/jm030841r. J Med Chem. 2003. PMID: 14667218

3

Synthesis and structure-activity relationships of a new model of arylpiperazines. Study of the 5-HT(1a)/alpha(1)-adrenergic receptor affinity by classical hansch analysis, artificial neural networks, and computational simulation of ligand recognition.

López-Rodríguez ML, Morcillo MJ, Fernández E, Rosado ML, Pardo L, Schaper K. López-Rodríguez ML, et al. J Med Chem. 2001 Jan 18;44(2):198-207. doi: 10.1021/jm000930t. J Med Chem. 2001. PMID: 11170629

4

Benzimidazole derivatives. 3. 3D-QSAR/CoMFA model and computational simulation for the recognition of 5-HT(4) receptor antagonists.

López-Rodríguez ML, Murcia M, Benhamú B, Viso A, Campillo M, Pardo L. López-Rodríguez ML, et al. J Med Chem. 2002 Oct 24;45(22):4806-15. doi: 10.1021/jm020807x. J Med Chem. 2002. PMID: 12383006

5

Design and synthesis of S-(-)-2-[[4-(napht-1-yl)piperazin-1-yl]methyl]-1,4-dioxoperhydropyrrolo[1,2-a]pyrazine (CSP-2503) using computational simulation. A 5-HT1A receptor agonist.

López-Rodríguez ML, Morcillo MJ, Fernández E, Benhamú B, Tejada I, Ayala D, Viso A, Olivella M, Pardo L, Delgado M, Manzanares J, Fuentes JA. López-Rodríguez ML, et al. Bioorg Med Chem Lett. 2003 Apr 17;13(8):1429-32. doi: 10.1016/s0960-894x(03)00160-4. Bioorg Med Chem Lett. 2003. PMID: 12668005

6

Design and synthesis of new benzimidazole-arylpiperazine derivatives acting as mixed 5-HT1A/5-HT3 ligands.

López-Rodríguez ML, Benhamú B, Morcillo MJ, Tejada I, Avila D, Marco I, Schiapparelli L, Frechilla D, Del Río J. López-Rodríguez ML, et al. Bioorg Med Chem Lett. 2003 Oct 6;13(19):3177-80. doi: 10.1016/s0960-894x(03)00706-6. Bioorg Med Chem Lett. 2003. PMID: 12951088

7

Benzimidazole derivatives. 4. The recognition of the voluminous substituent attached to the basic amino group of 5-HT4 receptor antagonists.

López-Rodríguez ML, Benhamú B, Murcia M, Alvaro E, Campillo M, Pardo L. López-Rodríguez ML, et al. J Comput Aided Mol Des. 2003 Aug;17(8):515-24. doi: 10.1023/b:jcam.0000004601.34056.c1. J Comput Aided Mol Des. 2003. PMID: 14703122

8

Synthesis and structure-activity relationships of a new model of arylpiperazines. 8. Computational simulation of ligand-receptor interaction of 5-HT(1A)R agonists with selectivity over alpha1-adrenoceptors.

López-Rodríguez ML, Morcillo MJ, Fernández E, Benhamú B, Tejada I, Ayala D, Viso A, Campillo M, Pardo L, Delgado M, Manzanares J, Fuentes JA. López-Rodríguez ML, et al. J Med Chem. 2005 Apr 7;48(7):2548-58. doi: 10.1021/jm048999e. J Med Chem. 2005. PMID: 15801844

9

A three-dimensional pharmacophore model for 5-hydroxytryptamine6 (5-HT6) receptor antagonists.

López-Rodríguez ML, Benhamú B, de la Fuente T, Sanz A, Pardo L, Campillo M. López-Rodríguez ML, et al. J Med Chem. 2005 Jun 30;48(13):4216-9. doi: 10.1021/jm050247c. J Med Chem. 2005. PMID: 15974573

10

Synthesis of new serotonin 5-HT7 receptor ligands. Determinants of 5-HT7/5-HT1A receptor selectivity.

Medina RA, Sallander J, Benhamú B, Porras E, Campillo M, Pardo L, López-Rodríguez ML. Medina RA, et al. J Med Chem. 2009 Apr 23;52(8):2384-92. doi: 10.1021/jm8014553. J Med Chem. 2009. PMID: 19326916

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