Lietha D - Search Results

1

A new crystal form of the NK1 splice variant of HGF/SF demonstrates extensive hinge movement and suggests that the NK1 dimer originates by domain swapping.

Watanabe K, Chirgadze DY, Lietha D, de Jonge H, Blundell TL, Gherardi E. Watanabe K, et al. Among authors: lietha d. J Mol Biol. 2002 May 31;319(2):283-8. doi: 10.1016/S0022-2836(02)00199-7. J Mol Biol. 2002. PMID: 12051906

2

Crystal structures of NK1-heparin complexes reveal the basis for NK1 activity and enable engineering of potent agonists of the MET receptor.

Lietha D, Chirgadze DY, Mulloy B, Blundell TL, Gherardi E. Lietha D, et al. EMBO J. 2001 Oct 15;20(20):5543-55. doi: 10.1093/emboj/20.20.5543. EMBO J. 2001. PMID: 11597998 Free PMC article.

3

The interactions of hepatocyte growth factor/scatter factor and its NK1 and NK2 variants with glycosaminoglycans using a modified gel mobility shift assay. Elucidation of the minimal size of binding and activatory oligosaccharides.

Lyon M, Deakin JA, Lietha D, Gherardi E, Gallagher JT. Lyon M, et al. Among authors: lietha d. J Biol Chem. 2004 Oct 15;279(42):43560-7. doi: 10.1074/jbc.M408510200. Epub 2004 Aug 2. J Biol Chem. 2004. PMID: 15292253 Free article.

4

The FERM domain: organizing the structure and function of FAK.

Frame MC, Patel H, Serrels B, Lietha D, Eck MJ. Frame MC, et al. Among authors: lietha d. Nat Rev Mol Cell Biol. 2010 Nov;11(11):802-14. doi: 10.1038/nrm2996. Nat Rev Mol Cell Biol. 2010. PMID: 20966971 Review.

5

Spatial and temporal regulation of focal adhesion kinase activity in living cells.

Cai X, Lietha D, Ceccarelli DF, Karginov AV, Rajfur Z, Jacobson K, Hahn KM, Eck MJ, Schaller MD. Cai X, et al. Among authors: lietha d. Mol Cell Biol. 2008 Jan;28(1):201-14. doi: 10.1128/MCB.01324-07. Epub 2007 Oct 29. Mol Cell Biol. 2008. PMID: 17967873 Free PMC article.

6

Alternative Activation Mechanisms of Protein Kinase B Trigger Distinct Downstream Signaling Responses.

Balzano D, Fawal MA, Velázquez JV, Santiveri CM, Yang J, Pastor J, Campos-Olivas R, Djouder N, Lietha D. Balzano D, et al. Among authors: lietha d. J Biol Chem. 2015 Oct 9;290(41):24975-85. doi: 10.1074/jbc.M115.651570. Epub 2015 Aug 18. J Biol Chem. 2015. PMID: 26286748 Free PMC article.

7

Structural basis of Focal Adhesion Kinase activation on lipid membranes.

Acebrón I, Righetto RD, Schoenherr C, de Buhr S, Redondo P, Culley J, Rodríguez CF, Daday C, Biyani N, Llorca O, Byron A, Chami M, Gräter F, Boskovic J, Frame MC, Stahlberg H, Lietha D. Acebrón I, et al. Among authors: lietha d. EMBO J. 2020 Oct 1;39(19):e104743. doi: 10.15252/embj.2020104743. Epub 2020 Aug 11. EMBO J. 2020. PMID: 32779739 Free PMC article.

8

A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.

Temps C, Lietha D, Webb ER, Li XF, Dawson JC, Muir M, Macleod KG, Valero T, Munro AF, Contreras-Montoya R, Luque-Ortega JR, Fraser C, Beetham H, Schoenherr C, Lopalco M, Arends MJ, Frame MC, Qian BZ, Brunton VG, Carragher NO, Unciti-Broceta A. Temps C, et al. Among authors: lietha d. Cancer Res. 2021 Nov 1;81(21):5438-5450. doi: 10.1158/0008-5472.CAN-21-0613. Epub 2021 Aug 20. Cancer Res. 2021. PMID: 34417202 Free PMC article.

9

New insights into FAK structure and function in focal adhesions.

Le Coq J, Acebrón I, Rodrigo Martin B, López Navajas P, Lietha D. Le Coq J, et al. Among authors: lietha d. J Cell Sci. 2022 Oct 15;135(20):jcs259089. doi: 10.1242/jcs.259089. Epub 2022 Oct 14. J Cell Sci. 2022. PMID: 36239192 Review.

10

Structural basis for the autoinhibition of focal adhesion kinase.

Lietha D, Cai X, Ceccarelli DF, Li Y, Schaller MD, Eck MJ. Lietha D, et al. Cell. 2007 Jun 15;129(6):1177-87. doi: 10.1016/j.cell.2007.05.041. Cell. 2007. PMID: 17574028 Free PMC article.

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