Marcinkeviciene J - Search Results

1

Novel inhibition of porcine pepsin by a substituted piperidine. Preference for one of the enzyme conformers.

Marcinkeviciene J, Kopcho LM, Yang T, Copeland RA, Glass BM, Combs AP, Falahatpisheh N, Thompson L. Marcinkeviciene J, et al. J Biol Chem. 2002 Aug 9;277(32):28677-82. doi: 10.1074/jbc.M203120200. Epub 2002 May 23. J Biol Chem. 2002. PMID: 12029090 Free article.

2

Kinetic studies on beta-site amyloid precursor protein-cleaving enzyme (BACE). Confirmation of an iso mechanism.

Toulokhonova L, Metzler WJ, Witmer MR, Copeland RA, Marcinkeviciene J. Toulokhonova L, et al. Among authors: marcinkeviciene j. J Biol Chem. 2003 Feb 14;278(7):4582-9. doi: 10.1074/jbc.M210471200. Epub 2002 Nov 27. J Biol Chem. 2003. PMID: 12458195 Free article.

3

Helicobacter pylori-selective antibacterials based on inhibition of pyrimidine biosynthesis.

Copeland RA, Marcinkeviciene J, Haque TS, Kopcho LM, Jiang W, Wang K, Ecret LD, Sizemore C, Amsler KA, Foster L, Tadesse S, Combs AP, Stern AM, Trainor GL, Slee A, Rogers MJ, Hobbs F. Copeland RA, et al. Among authors: marcinkeviciene j. J Biol Chem. 2000 Oct 27;275(43):33373-8. doi: 10.1074/jbc.M004451200. J Biol Chem. 2000. PMID: 10938275 Free article.

4

Mechanism of Inhibition of beta-site amyloid precursor protein-cleaving enzyme (BACE) by a statine-based peptide.

Marcinkeviciene J, Luo Y, Graciani NR, Combs AP, Copeland RA. Marcinkeviciene J, et al. J Biol Chem. 2001 Jun 29;276(26):23790-4. doi: 10.1074/jbc.M101896200. Epub 2001 Apr 16. J Biol Chem. 2001. PMID: 11306583 Free article.

5

Synthesis and SAR of indole-and 7-azaindole-1,3-dicarboxamide hydroxyethylamine inhibitors of BACE-1.

Marcin LR, Higgins MA, Zusi FC, Zhang Y, Dee MF, Parker MF, Muckelbauer JK, Camac DM, Morin PE, Ramamurthy V, Tebben AJ, Lentz KA, Grace JE, Marcinkeviciene JA, Kopcho LM, Burton CR, Barten DM, Toyn JH, Meredith JE, Albright CF, Bronson JJ, Macor JE, Thompson LA. Marcin LR, et al. Among authors: marcinkeviciene ja. Bioorg Med Chem Lett. 2011 Jan 1;21(1):537-41. doi: 10.1016/j.bmcl.2010.10.079. Bioorg Med Chem Lett. 2011. PMID: 21078556

6

Parallel synthesis of potent, pyrazole-based inhibitors of Helicobacter pylori dihydroorotate dehydrogenase.

Haque TS, Tadesse S, Marcinkeviciene J, Rogers MJ, Sizemore C, Kopcho LM, Amsler K, Ecret LD, Zhan DL, Hobbs F, Slee A, Trainor GL, Stern AM, Copeland RA, Combs AP. Haque TS, et al. Among authors: marcinkeviciene j. J Med Chem. 2002 Oct 10;45(21):4669-78. doi: 10.1021/jm020112w. J Med Chem. 2002. PMID: 12361393

7

Comparative studies of active site-ligand interactions among various recombinant constructs of human beta-amyloid precursor protein cleaving enzyme.

Kopcho LM, Ma J, Marcinkeviciene J, Lai Z, Witmer MR, Cheng J, Yanchunas J, Tredup J, Corbett M, Calambur D, Wittekind M, Paruchuri M, Kothari D, Lee G, Ganguly S, Ramamurthy V, Morin PE, Camac DM, King RW, Lasut AL, Ross OH, Hillman MC, Fish B, Shen K, Dowling RL, Kim YB, Graciani NR, Collins D, Combs AP, George H, Thompson LA, Copeland RA. Kopcho LM, et al. Among authors: marcinkeviciene j. Arch Biochem Biophys. 2003 Feb 15;410(2):307-16. doi: 10.1016/s0003-9861(02)00690-2. Arch Biochem Biophys. 2003. PMID: 12573291

8

Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach.

Kopcho LM, Kim YB, Wang A, Liu MA, Kirby MS, Marcinkeviciene J. Kopcho LM, et al. Among authors: marcinkeviciene j. Arch Biochem Biophys. 2005 Apr 15;436(2):367-76. doi: 10.1016/j.abb.2005.02.015. Arch Biochem Biophys. 2005. PMID: 15797249

9

Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118).

Kim YB, Kopcho LM, Kirby MS, Hamann LG, Weigelt CA, Metzler WJ, Marcinkeviciene J. Kim YB, et al. Among authors: marcinkeviciene j. Arch Biochem Biophys. 2006 Jan 1;445(1):9-18. doi: 10.1016/j.abb.2005.11.010. Epub 2005 Dec 5. Arch Biochem Biophys. 2006. PMID: 16364232

10

[3H]BMS-599240--a novel tritiated ligand for the characterization of BACE1 inhibitors.

Iben LG, Kopcho L, Marcinkeviciene J, Zheng C, Thompson LA, Albright CF, Toyn JH. Iben LG, et al. Among authors: marcinkeviciene j. Eur J Pharmacol. 2008 Sep 28;593(1-3):10-5. doi: 10.1016/j.ejphar.2008.06.112. Epub 2008 Jul 11. Eur J Pharmacol. 2008. PMID: 18655784

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