Zachariou A - Search Results

1

The DIAP1 RING finger mediates ubiquitination of Dronc and is indispensable for regulating apoptosis.

Wilson R, Goyal L, Ditzel M, Zachariou A, Baker DA, Agapite J, Steller H, Meier P. Wilson R, et al. Among authors: zachariou a. Nat Cell Biol. 2002 Jun;4(6):445-50. doi: 10.1038/ncb799. Nat Cell Biol. 2002. PMID: 12021771

2

The antiapoptotic activity of insect IAPs requires activation by an evolutionarily conserved mechanism.

Tenev T, Ditzel M, Zachariou A, Meier P. Tenev T, et al. Among authors: zachariou a. Cell Death Differ. 2007 Jun;14(6):1191-201. doi: 10.1038/sj.cdd.4402118. Epub 2007 Mar 9. Cell Death Differ. 2007. PMID: 17347664

3

Jafrac2 is an IAP antagonist that promotes cell death by liberating Dronc from DIAP1.

Tenev T, Zachariou A, Wilson R, Paul A, Meier P. Tenev T, et al. Among authors: zachariou a. EMBO J. 2002 Oct 1;21(19):5118-29. doi: 10.1093/emboj/cdf530. EMBO J. 2002. PMID: 12356728 Free PMC article.

4

Degradation of DIAP1 by the N-end rule pathway is essential for regulating apoptosis.

Ditzel M, Wilson R, Tenev T, Zachariou A, Paul A, Deas E, Meier P. Ditzel M, et al. Among authors: zachariou a. Nat Cell Biol. 2003 May;5(5):467-73. doi: 10.1038/ncb984. Nat Cell Biol. 2003. PMID: 12692559

5

IAP-antagonists exhibit non-redundant modes of action through differential DIAP1 binding.

Zachariou A, Tenev T, Goyal L, Agapite J, Steller H, Meier P. Zachariou A, et al. EMBO J. 2003 Dec 15;22(24):6642-52. doi: 10.1093/emboj/cdg617. EMBO J. 2003. PMID: 14657035 Free PMC article.

6

IAPs are functionally non-equivalent and regulate effector caspases through distinct mechanisms.

Tenev T, Zachariou A, Wilson R, Ditzel M, Meier P. Tenev T, et al. Among authors: zachariou a. Nat Cell Biol. 2005 Jan;7(1):70-7. doi: 10.1038/ncb1204. Epub 2004 Dec 5. Nat Cell Biol. 2005. PMID: 15580265

7

Systematic in vivo RNAi analysis of putative components of the Drosophila cell death machinery.

Leulier F, Ribeiro PS, Palmer E, Tenev T, Takahashi K, Robertson D, Zachariou A, Pichaud F, Ueda R, Meier P. Leulier F, et al. Among authors: zachariou a. Cell Death Differ. 2006 Oct;13(10):1663-74. doi: 10.1038/sj.cdd.4401868. Epub 2006 Feb 17. Cell Death Differ. 2006. PMID: 16485033

8

The Ripoptosome, a signaling platform that assembles in response to genotoxic stress and loss of IAPs.

Tenev T, Bianchi K, Darding M, Broemer M, Langlais C, Wallberg F, Zachariou A, Lopez J, MacFarlane M, Cain K, Meier P. Tenev T, et al. Among authors: zachariou a. Mol Cell. 2011 Aug 5;43(3):432-48. doi: 10.1016/j.molcel.2011.06.006. Epub 2011 Jul 7. Mol Cell. 2011. PMID: 21737329 Free article.

9

Biallelic TRIP13 mutations predispose to Wilms tumor and chromosome missegregation.

Yost S, de Wolf B, Hanks S, Zachariou A, Marcozzi C, Clarke M, de Voer R, Etemad B, Uijttewaal E, Ramsay E, Wylie H, Elliott A, Picton S, Smith A, Smithson S, Seal S, Ruark E, Houge G, Pines J, Kops GJPL, Rahman N. Yost S, et al. Among authors: zachariou a. Nat Genet. 2017 Jul;49(7):1148-1151. doi: 10.1038/ng.3883. Epub 2017 May 29. Nat Genet. 2017. PMID: 28553959 Free PMC article.

10

Phase 1, dose-escalation study of guadecitabine (SGI-110) in combination with pembrolizumab in patients with solid tumors.

Papadatos-Pastos D, Yuan W, Pal A, Crespo M, Ferreira A, Gurel B, Prout T, Ameratunga M, Chénard-Poirier M, Curcean A, Bertan C, Baker C, Miranda S, Masrour N, Chen W, Pereira R, Figueiredo I, Morilla R, Jenkins B, Zachariou A, Riisnaes R, Parmar M, Turner A, Carreira S, Yap C, Brown R, Tunariu N, Banerji U, Lopez J, de Bono J, Minchom A. Papadatos-Pastos D, et al. Among authors: zachariou a. J Immunother Cancer. 2022 Jun;10(6):e004495. doi: 10.1136/jitc-2022-004495. J Immunother Cancer. 2022. PMID: 35717027 Free PMC article. Clinical Trial.

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