Koehn FE - Search Results

1

Pyrazolopyrimidine-2,4-dione sulfonamides: novel and selective calcitonin inducers.

Gilbert AM, Caltabiano S, Koehn FE, Chen ZJ, Francisco GD, Ellingboe JW, Kharode Y, Mangine A, Francis R, TrailSmith M, Gralnick D. Gilbert AM, et al. Among authors: koehn fe. J Med Chem. 2002 May 23;45(11):2342-5. doi: 10.1021/jm010554s. J Med Chem. 2002. PMID: 12014973

2

New strategies and methods in the discovery of natural product anti-infective agents: the mannopeptimycins.

Koehn FE. Koehn FE. J Med Chem. 2008 May 8;51(9):2613-7. doi: 10.1021/jm070432l. Epub 2008 Apr 5. J Med Chem. 2008. PMID: 18393404 Review. No abstract available.

3

Hydrophobic acetal and ketal derivatives of mannopeptimycin-alpha and desmethylhexahydromannopeptimycin-alpha: semisynthetic glycopeptides with potent activity against Gram-positive bacteria.

Dushin RG, Wang TZ, Sum PE, He H, Sutherland AG, Ashcroft JS, Graziani EI, Koehn FE, Bradford PA, Petersen PJ, Wheless KL, How D, Torres N, Lenoy EB, Weiss WJ, Lang SA, Projan SJ, Shlaes DM, Mansour TS. Dushin RG, et al. Among authors: koehn fe. J Med Chem. 2004 Jul 1;47(14):3487-90. doi: 10.1021/jm049765y. J Med Chem. 2004. PMID: 15214775

4

6-Substituted-4-(3-bromophenylamino)quinazolines as putative irreversible inhibitors of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor (HER-2) tyrosine kinases with enhanced antitumor activity.

Tsou HR, Mamuya N, Johnson BD, Reich MF, Gruber BC, Ye F, Nilakantan R, Shen R, Discafani C, DeBlanc R, Davis R, Koehn FE, Greenberger LM, Wang YF, Wissner A. Tsou HR, et al. Among authors: koehn fe. J Med Chem. 2001 Aug 16;44(17):2719-34. doi: 10.1021/jm0005555. J Med Chem. 2001. PMID: 11495584

5

Synthesis and evaluation of ether and halogenated derivatives of mannopeptimycin glycopeptide antibiotics.

Sum PE, How D, Torres N, Petersen PJ, Ashcroft J, Graziani EI, Koehn FE, Mansour TS. Sum PE, et al. Among authors: koehn fe. Bioorg Med Chem Lett. 2003 Aug 18;13(16):2805-8. doi: 10.1016/s0960-894x(03)00542-0. Bioorg Med Chem Lett. 2003. PMID: 12873519

6

Mannopeptimycin esters and carbonates, potent antibiotic agents against drug-resistant bacteria.

He H, Shen B, Petersen PJ, Weiss WJ, Yang HY, Wang TZ, Dushin RG, Koehn FE, Carter GT. He H, et al. Among authors: koehn fe. Bioorg Med Chem Lett. 2004 Jan 5;14(1):279-82. doi: 10.1016/j.bmcl.2003.09.071. Bioorg Med Chem Lett. 2004. PMID: 14684343

7

Probing natural product biosynthetic pathways using Fourier transform ion cyclotron resonance mass spectrometry.

Feng X, Ratnayake AS, Charan RD, Janso JE, Bernan VS, Schlingmann G, He H, Tischler M, Koehn FE, Carter GT. Feng X, et al. Among authors: koehn fe. Bioorg Med Chem. 2009 Mar 15;17(6):2154-61. doi: 10.1016/j.bmc.2008.10.073. Epub 2008 Nov 5. Bioorg Med Chem. 2009. PMID: 19028101

8

Mapping the bound conformation and protein interactions of microtubule destabilizing peptides by STD-NMR spectroscopy.

Milton MJ, Thomas Williamson R, Koehn FE. Milton MJ, et al. Among authors: koehn fe. Bioorg Med Chem Lett. 2006 Aug 15;16(16):4279-82. doi: 10.1016/j.bmcl.2006.05.067. Epub 2006 Jun 12. Bioorg Med Chem Lett. 2006. PMID: 16765596

9

Amphotericin B, identified from a natural product screen, antagonizes CNS inhibitors to promote axon growth via activation of an Akt pathway in neurons.

Gao Y, Deng K, Cao Z, Graziani EI, Gilbert AM, Koehn FE, Wood A, Doherty P, Walsh FS. Gao Y, et al. Among authors: koehn fe. J Neurochem. 2010 Jun;113(5):1331-42. doi: 10.1111/j.1471-4159.2010.06704.x. Epub 2010 Mar 25. J Neurochem. 2010. PMID: 20345749 Free article.

10

The evolving role of natural products in drug discovery.

Koehn FE, Carter GT. Koehn FE, et al. Nat Rev Drug Discov. 2005 Mar;4(3):206-20. doi: 10.1038/nrd1657. Nat Rev Drug Discov. 2005. PMID: 15729362 Review.

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