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The late addition of core lipids to nascent apolipoprotein B100, resulting in the assembly and secretion of triglyceride-rich lipoproteins, is independent of both microsomal triglyceride transfer protein activity and new triglyceride synthesis.
Pan M, Liang Js JS, Fisher EA, Ginsberg HN. Pan M, et al. Among authors: fisher ea. J Biol Chem. 2002 Feb 8;277(6):4413-21. doi: 10.1074/jbc.M107460200. Epub 2001 Nov 9. J Biol Chem. 2002. PMID: 11704664 Free article.
The amino-terminal domain of apolipoprotein B does not undergo retrograde translocation from the endoplasmic reticulum to the cytosol. Proteasomal degradation of nascent apolipoprotein B begins at the carboxyl terminus of the protein, while apolipoprotein B is still in its original translocon.
Liang S, Wu X, Fisher EA, Ginsberg HN. Liang S, et al. Among authors: fisher ea. J Biol Chem. 2000 Oct 13;275(41):32003-10. doi: 10.1074/jbc.M004646200. J Biol Chem. 2000. PMID: 10922368 Free article.
466 results